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Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis

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Abstract

This systematic review and meta-analysis evaluated changes in circulating irisin levels after bariatric surgery. A systematic search was performed across Embase, Scopus, PubMed, and Web of Science for this study. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was depicted through a random-effects meta-analysis and the leave-one-out method. The meta-analysis, which included 13 studies with a total of 407 participants, showed a statistically non-significant reduction in circulating irisin levels following bariatric surgery (SMD:  – 0.089, 95% CI  – 0.281, 0.102, 95% PI:  – 0.790, 0.611, p = 0.360; I2:70.56). Our research found no significant change in irisin levels after bariatric surgery. Moreover, these findings were not associated with the type of surgery or the duration of follow-up.

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Authors and Affiliations

  1. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Tannaz Jamialahamdi

  2. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Tannaz Jamialahamdi

  3. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Elaheh Mirhadi

  4. Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates

    Wael Almahmeed

  5. Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar

    Ali H. Eid

  6. Medical Research Centre, Sultan Qaboos University, Muscat, Oman

    Khalid Al-Rasadi

  7. Department of Biochemistry, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman

    Khalid Al-Rasadi

  8. Department of Surgery, University of California Irvine Medical Center, Orange, CA, USA

    Ninh T. Nguyen & Kishore M. Gadde

  9. Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

    Amirhossein Sahebkar

  10. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  11. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

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  1. Tannaz Jamialahamdi
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Correspondence to Amirhossein Sahebkar.

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Jamialahamdi, T., Mirhadi, E., Almahmeed, W. et al. Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis. Updates Surg (2024). https://doi.org/10.1007/s13304-024-01866-8

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