Abstract
Introduction
There is considerable evidence for diabetes reducing quality of life. The impact of such a diagnosis on mental health is less well understood and was subsequently explored here.
Methods
Online PHQ-9 scores (which calculate the severity of depression), Diabetes Distress Screening Scale (DDSS) and EQ-5D-5L (quality-of-life) questionnaires were completed by patients with diabetes, followed by the extraction of data where possible from responders’ clinical records.
Results
A total of 133 people submitted questionnaires. However, not all data items could be completed by each patient; 35% (45/130) had type I diabetes mellitus (T1DM); 55% (64/117) were women. The overall median age of 117 responders was 60 (IQR 50–68 years). The median aggregated response scores were: EQ-5D-5L 0.74 (IQR 0.64–0.85) (lower quality of life than UK population median of 0.83), DDSS 1.9 (IQR1.3–2.7) (≥ 2 indicates moderate distress) and PHQ-9 5 (IQR2-11) (≥ 5 indicates depression). Higher diabetes distress (DDSS)/lower quality of life EQ-5D-5L/higher depressive symptoms (PHQ-9) linked to female sex (DDSS 0.5/25% above median), younger age (< 50 years DDSS 0.7/35% above median), fewer years after diagnosis (< 10 years DDSS 0.8/40% above median), and obesity (BMI > 35 DDSS 0.6/30% above median). Additionally, a HbA1c reading of ≤ 48 mmol/mol was associated with higher DDSS scores, as did a reduction of more than 5 mmol/mol in HbA1c over the last three HbA1c measurements. The 30 individuals with a history of prescribed antidepressant medication also showed higher diabetes distress scores (DDSS 0.9, equating to 45% above the median). The DDSS score elevation came from an increase in emotional burden and regimen-related distress. DDSS scores were not significantly linked to diabetes type, insulin use, absolute level/change in blood glucose HbA1c. Physician-related distress showed a similar pattern.
Conclusions
A low level of stress in relation to diabetes management may be associated with lower HbA1c. The larger impact of diabetes on mental health in younger women/people with shorter diabetes duration should be noted when considering psychosocial intervention/behavior change messaging. Physician-related distress is a potentially remediable factor. However, this sample was self-selecting, limiting generalization to other samples.
Similar content being viewed by others
Avoid common mistakes on your manuscript.
The presence of symptoms of depression in people with diabetes is associated with reduced self-care compared to people with diabetes alone. We conducted an online survey in which PHQ-9 (depression), Diabetes Distress Screening Scale (DDSS) and EQ-5D-5L (quality-of-life) questionnaires were completed by people with diabetes. |
Higher diabetes distress (DDSS)/lower quality of life EQ-5D-5L/higher depressive symptoms (PHQ-9) linked to female sex (DDSS 0.5/25% above median), younger age (< 50 years DDSS 0.7/35% above median), fewer years after diagnosis (< 10 years DDSS 0.8/40% above median), and obesity (BMI > 35 DDSS 0.6/30% above median). Additionally, a HbA1c reading of ≤ 48 mmol/mol (6.5%) was associated with higher DDSS scores, as did a reduction of more than 5 mmol/mol in HbA1c over the last three HbA1c measurements. |
A low level of stress in relation to diabetes management may be associated with lower HbA1c levels. The larger impact of diabetes on mental health in younger female patients and/or people with shorter diabetes duration should be noted when considering psychosocial intervention/behavior change messaging. Physician-related distress is a potentially remediable factor. |
Introduction
People with diabetes often experience low mood. Up to 19% of people with type 2 diabetes mellitus (T2DM) have been diagnosed with a major depressive disorder, and up to 25% have clinically relevant depression symptoms at any time [1,2,3,4]. The prevalence rate of depression is more than three-times higher in people with type 1 diabetes mellitus (T1DM) and nearly twice as high in people with T2DM, compared to those without these conditions [5]. Both women with and without diabetes experience a higher prevalence of depression than men [5].
The presence of symptoms of depression in people with diabetes is associated with reduced self-care compared to people with diabetes alone [6, 7]. Depressive symptoms are also associated with adverse health outcomes, such as poor blood glucose control [8], more diabetes complications [8, 9], poorer quality of life [10], higher health care costs [11], and a higher mortality rate [12].
Diabetes distress is a prominent issue in people with T2DM and has been associated with female gender and comorbid depressive symptoms [13]. Diabetes distress has many causes including fear of complications, frustration with having diabetes itself, and perceived or real lifestyle constriction because of the diagnosis [14]. Given the high prevalence of co-morbid depression and associated adverse health outcomes, it has been recommended to screen for depressive symptoms in people with diabetes on a regular basis and to provide treatment whenever possible [15].
Most United Kingdom (UK) diabetes teams, whether based in the hospital or the community, are under-resourced with regards to access to clinical psychology. Therefore, this is an area of significant unmet need that merits an up-to-date formal evaluation how patient experience may inform effective targeting of limited resources.
We report the results of an online survey to evaluate how depression and diabetes distress affected people with diabetes in the UK in 2020 and 2021. We also considered how reports of low mood and distress related to both demographic/anthropometric factors and to blood glucose control.
Methods
We conducted an online survey utilizing the resource provided by Research for the Future (RfTF) [16] in relation to people’s lived experience of diabetes regarding mood and diabetes-related distress. RfTF is an NHS-supported organization which encourages people to become more involved with health research in their local area. Most people who volunteer to be part of RfTF live in the Greater Manchester conurbation but approximately 6% live elsewhere in the UK. There were no specific inclusion criteria—rather this was online survey of our volunteers in RfTF [16].
In this study, we were particularly interested in how the DDSS scores related to other factors such as perception of care given, medical history, and mode of treatment. The survey was conducted online in late 2020 and early 2021 at the time of the COVID-19 global pandemic. Ethical approval was obtained from the Greater Manchester West Research Ethics Committee, REC reference 20/NW/0252.
There are an estimated 110,000 people living with diabetes in the Greater Manchester conurbation. There are 2800 people with diabetes in the RfTF database. Of these, 1100 were invited to participate in the online survey.
Participants gave permission for their general practice records to be accessed. Informed consent was obtained from all participants. In some cases (n = 88), this was possible through the Greater Manchester care Record [17] and in other cases (n = 42) through the NHS Digital Spine [18]. Specifically, we asked questions about mood, motivation, quality of life and diabetes distress. The questionnaires used were: EQ-5D-5L [19], PHQ-9 (depression) [20] and Diabetes Distress Screening Scale (DDSS) [21]. These were adapted for online use. Diabetes Distress (DDSS) scores were evaluated by counting the number of questions with response > 2 (“1—Not a problem” or “2—a slight problem”), in total and by sub-scale.
The DDSS is derived from 17-item five level Likert scale responses reflected into four subscales that target different areas of potential diabetes-specific distress to help clinicians and patients identify areas where interventions might be helpful: emotional burden (feeling overwhelmed by diabetes), physician-related distress (worries about access, trust, and care), regimen-related distress (concerns about diet, physical activity, medications), and interpersonal distress (not receiving understanding and appropriate support from others). Average scores of any sub-scale over three or more is considered to indicate significant distress for that person in that area [21].
The PHQ-9 scale is a multipurpose instrument for screening and for monitoring the severity of depression [18]. The EQ-5D-5L is a descriptive system to estimate quality of life (QOL) [19], comprising five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each dimension has five levels: no problems, slight problems, moderate problems, severe problems, and extreme problems. Participants are asked to indicate their health state by ticking the box next to the most appropriate statement in each of the five dimensions [19].
The response scores were collected and analyzed.
EQ5D: each patient’s response profile was cross walked applying the EuroQoL (https://euroqol.org/eq-5d-instruments/eq-5d-5l-about/valuation-standard-value-sets/crosswalk-index-value-calculator/) tool using UK data to establish their EQ5D score.
DDS: The average score and the number of responses of three or higher for each of the five aspects plus the overall total were calculated.
PHQ-9: The total score over the nine items were added together (Minimal 0–4, Mild 5–9, Moderate 10–14, Moderately Severe 15–19, Severe ≥ 20).
Other patients’ characteristics were taken from the response questionnaire and heath records where available; these included diabetes type, sex, age, body mass index (BMI), duration with diabetes in years, diabetes medication being used, history of antidepressant use, HbA1c (self-reported in questionnaire and taken from health records) over various time frames. Univariant analysis was applied linking average response levels to various classes of patients. To highlight differences, the ratio of the response level within a class was taken against the overall average response.
Multivariant analysis was applied by regression linking the overall DDS average score to diabetes type, sex, age, BMI, duration, HbA1c, antidepressant use, insulin use, and self-health score. Factors with the highest p values were removed stepwise.
Results
A total of 133 people completed the questionnaire; however, not all data items could then be extracted for all responders’ medical records; 35% (45/130) were T1DM, 55% (64/117) were women. The median age was 60 (interquartile range (IQR) 47–67) years. The overall median scores were: EQ-5D-5L = 0.74 (IQR 0.64–0.85) (lower QOL than UK population median 82.8), DDSS = 1.9 (IQR1.3–2.7) (≥ 2 indicates moderate distress) and PHQ-9 = 5 (IQR 2–11) (≥ 5 indicates depression). Compared with UK prevalence figures, there was a fivefold over-representation of people with T1DM and consequent under-representation of people with T2DM (68%). The questionnaire's 31 items were internally consistent both across and within each questionnaire with overall Cronbach’s alpha (measure of the internal consistency of the scales) [31 items] 0.95, EQ-5D-5L (raw scores) (five items) 0.85, overall DDSS (17 items) 0.95 and PHQ-9 (nine items) 0.95.
Diabetes Distress Scale Scores
Figure 1A shows the level of response for all patients across each question. The most serious concerns and related distress were related to: the prospect of longer-term complications; a sense that diabetes controls the person’s life; concerns about not sticking closely to a good meal plan; failing with the diabetes routine; being overwhelmed by the demands of living with diabetes and not having a doctor that they can see regularly enough about their diabetes.
Figure 1B shows the sum of response levels for each participant as a percentage of the 17 items. The y-axis shows the % rank for each participant out of total of 133 providing responses. This varied considerably, with the top 20% participants having 90% responses > 2 and the lowest 30% having almost no responses > 2.
Figure 1C shows the total number of responses > 2 for each participant as % of 17 for each sub-class of items. Forty-one (31%) individuals had no significant distress in any sub-scale, 16 (12%) had distress in one sub-scale and 26 (20%) had distress in two, 24 (18%) in three subscales, and 26 (20%) had at least one distress score > 2 in all sub-scales.
The split of the 92 (69%) participants with at least 1 score > 2 across the sub-scale was emotional burden 77 (58% of total patients), regimen-related distress 69 (52%), interpersonal distress 51 (38%), and physician-related distress 47 (35%).
Medication Prescription
Of those for whom medication information was available (116/133), 30% of people were being prescribed antidepressant treatment or had been prescribed an antidepressant in the previous 10 years; 3% were prescribed propranolol and 2% were prescribed diazepam. As shown in Fig. 2, the most prescribed antidepressant medication was sertraline (37.5% of those on an antidepressant) followed by citalopram (28% of those on an antidepressant). Other antidepressants prescribed are shown in Fig. 2. Amitriptyline was prescribed to manage neuropathic pain (at the dose of 10–50 mg) in 6% of individuals. Duloxetine was prescribed for both treatment of neuropathic pain and/or for treatment of low mood (at the dose of 60-120 mg daily).
In univariate analysis, lower scores reflecting higher DDSS/lower quality of life EQ-5D-5L/and higher depression (PHQ-9) were linked to female sex (DDSS 0.5 = 25% above median for the whole sample), younger age (< 50 years DDSS 0.7 = 35% above median), fewer years after initial diagnosis (< 10 years DDSS 0.8 = 40% above median), and obesity (BMI > 35 DDSS 0.6 = 30% above median). Lower DDSS scores were associated with a longer duration of diabetes.
Patients with a history of prescribed antidepressant medication showed higher diabetes distress scores (average DDSS score 2.8) compared to those with no history of antidepressant use (1.9, i.e., 47% higher). The DDSS score elevation particularly came from increases in emotional burden and regimen-related distress (Table 1).
The DDSS responses > 2 related closely to the total DDSS score (r2 = 0.9) as shown in Fig. 3A. There was a stronger relation between total DDSS scores for the respondents and the PHQ-9 score (r2 = 0.4) and a weaker relation between a higher DDSS score and lower EQ-5D-5L score (r2 = 0.1). (Fig. 3B). Each of the DDDS domains related strongly to the total DDSS score (Fig. 3C). There was no relation between self-assessed general health and the total DDSS score (Fig. 3D).
In Table 1, we describe how the scores for EQ-5D-5L, PHQ-9, and DDSS related to participant characteristics, body mass index (BMI), and HbA1c. Scores are described as a percentage of the median score for the scale or subscale. Higher DDSS and PHQ-9 scores and lower EQ-5D-5L scores were reported for women, those with a shorter duration of diabetes and those with history of antidepressant use, with insulin use associated higher EQ-5D-5L scores and lower DDSS and PHQ-9 scores. Body mass index (BMI) was only associated with less favorable life experience for people with a BMI of 40 kg/m2 or more. Greater physician-related distress was associated with female sex, younger age, BMI ≥ 40, shorter duration of diabetes and insulin treatment plus history of antidepressant use.
In Table 2, we describe how the average DDSS related to HbA1c. Both a high and low self-reported HbA1c was associated with higher DDSS scores as was HbA1c ≤ 48 mmol/mol and the perception that HbA1c was higher than it was in reality. A reduction of more than 5 mmol/mol in HbA1c over the last three HbA1c measurements was associated with higher DDSS scores. A similar pattern was seen for physician-related distress.
In multivariate analysis (r2 for the model 0.2) including all factors described in Tables 1 and 2 (Fig. 4), after stepwise removal only two variables remained with statistically significant low p values in relation to DDSS score; these were younger age (p = 0.045) and a shorter duration of diabetes (p = 0.002). Each of these was associated with a higher overall average DDSS score.
Discussion
In this study, we have characterized the experience of living with diabetes in those people who have responded to the online survey. The main findings were that higher diabetes distress, lower quality of life, and more depressive symptoms were associated with female sex, younger age, obesity, and being less than 10 years from diagnosis. Multiple regression analyses indicated that younger patients were more likely to experience severe diabetes distress as were people with a shorter duration of diabetes and those with a history of antidepressant use.
The Diabetes Distress Screening Scale (DDSS) score elevation came from increases in emotional burden and regimen-related Distress. It was apparent that people who could be considered to have excellent blood glucose control (HbA1c 48 mmol/mol (6.5%) or less) had higher levels of reported distress than those with higher HbA1c. This raises the question of whether it may be helpful to the achievement of optimal blood glucose control to have a low level of concern about the condition and its management. This requires further evaluation as stated by Nouwen et al. recently [22].
Individuals with the highest DDSS score [21] also reported on average a lower quality of their relationships with health care professionals, and more physical health-related distress (Fig. 3C). The importance of this observation is that it relates to opportunities for healthcare professionals to put more emphasis on psychological aspects during diabetes care consultations, as recently highlighted [23]. However, in a recent systematic review, it was concluded that psychological approaches in diabetes management need to be matched to the person and their life course [24].
Importantly, greater physician-related distress was associated with female sex, younger age, BMI > 40, shorter duration of diabetes and history of antidepressant use. This is relevant to the targeting of resources to the most at-risk individuals and to the way that people with diabetes interact with and experience the health care system and their appointments is something that can be influenced by health policy and by resource allocation.
Clinically significant depression was reportedly present in up to one of every four people with T2DM [25]. The findings of this study should be placed in the context of that and similar observations. It has previously been reported that women without diabetes experience a higher prevalence of depression than men [5]. The same review showed that women with and without diabetes have higher prevalence of depression. It is also the case that in our study, longer duration of diabetes was associated with less severe symptoms. Previously it was described that the association between duration of diabetes and risk of current depression was 'J-shaped' with the odds ratios decreasing and then increasing with greater duration of diabetes since diagnosis [26,27,28].
The finding of no statistically significant differences in DDSS scores for people taking insulin vs. those not on insulin may relate to the greater contact that people taking insulin have with health care professionals and greater personal support. This contrasts with several previous studies in this area [9].
The period since March 2020 in relation to the COVID-19 pandemic has been a very difficult time for anyone with diabetes in relation to the elevated risk of serious consequences of a COVID-19 infection [29,30,31], coupled with the way many general practices in the UK had to direct services away from long-term condition-monitoring clinics [32]. This has impacted the HbA1c testing interval and regularity [33] and other aspects of routine clinical care for people with all forms of diabetes [34].
To contextualize our findings, in a landmark systematic review, Nouwen et al. recently reported a bidirectional longitudinal association between depressive symptoms and HbA1c [9]. However, the observed effect sizes were small. The authors recommended that future studies should investigate the role of type of diabetes and depression, diabetes distress, and diabetes self-management behaviors.
In relation to the matter of self-management, we previously described the way that perception of current/future consequences of blood glucose level relate to blood glucose levels [35, 36] and found that in T2DM, for those with reported HbA1c ≥ 65 mmol/mol (8.1%), most people questioned (70%) were either concerned or really concerned about the shorter-term consequences of running a high HbA1c level. The group surveyed comprised engaged people with T2DM, but even within this group there was significant variation in (a) awareness of shorter-term risks, (b) confidence in their ability to implement appropriate insulin dosage, and (c) awareness of the limitations of BG monitoring technology. The authors suggested that this is an area where changes in education/support would benefit many.
We accept that this study has a small sample size and that the respondents were self-selecting in that they responded to an online survey. This was not intended as a prevalence study, but rather a study aiming to describe the characteristics of depression and distress in people with diabetes. However, we were able to gain information from the digital health records in most cases in relation to age, duration of diabetes since diagnosis, medication, and HbA1c/BMI with their explicit permission. There was an over-representation of people with T1DM vs. T2DM in relation to National Diabetes Audit (NDA) proportions [37]. This has also been noted in other surveys of patient experience.
Conclusions
The larger impact of diabetes on mental health in younger women and in people with a shorter duration of diabetes, or who are overweight, should be noted when considering psychosocial intervention and behavior change messaging. A low level of stress in relation to diabetes management appears to be associated with the achievement of better blood glucose control.
We suggest that these factors be considered when planning psychosocial interventions and behavior change messaging to support people with diabetes, in relation to the multiple challenges that they face, particularly given the impact of the COVID-19 pandemic on routine care for people with diabetes in the UK and elsewhere. Furthermore, physician-related distress, as reported here, can be addressed by changing the way that people with diabetes interact with and experience the health care system.
References
Ali S, Stone MA, Peters JL, Davies MJ, Khunti K. The prevalence of co-morbid depression in adults with type 2 diabetes: a systematic review and meta-analysis. Diabet Med. 2006;23:1165–73.
Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;2001(24):1069–107.
Barnard KD, Skinner TC, Peveler R. The prevalence of co-morbid depression in adults with type 1 diabetes: systematic literature review. Diabet Med. 2006;23:445–8.
Lloyd CE, Roy T, Nouwen A, Chauhan AM. Epidemiology of depression in diabetes: international and cross-cultural issues. J Affect Disord. 2012;142(Suppl):S22–9.
Roy T, Lloyd CE. Epidemiology of depression and diabetes: a systematic review. J Affect Disord. 2012;142(Suppl):S8-21.
Devarajooh C, Chinna K. Depression, distress and self-efficacy: The impact on diabetes self-care practices. PLoS ONE. 2017;12: e0175096.
van der Feltz-Cornelis C, Allen SF, Holt RIG, Roberts R, Nouwen A, Sartorius N. Treatment for comorbid depressive disorder or subthreshold depression in diabetes mellitus: systematic review and meta-analysis. Brain Behav. 2021;11: e01981.
Mansori K, Shiravand N, Shadmani FK, Moradi Y, Allahmoradi M, Ranjbaran M, Ahmadi S, Farahani A, Samii K, Valipour M. Association between depression with glycemic control and its complications in type 2 diabetes. Diabetes Metab Syndr. 2019;13:1555–60.
Nouwen A, Adriaanse MC, van Dam K, Iversen MM, Viechtbauer W, Peyrot M, Caramlau I, Kokoszka A, Kanc K, de Groot M, Nefs G, Pouwer F, European Depression in Diabetes (EDID) Research Consortium. Longitudinal associations between depression and diabetes complications: a systematic review and meta-analysis. Diabet Med. 2019;36:1562–72.
Zurita-Cruz JN, Manuel-Apolinar L, Arellano-Flores ML, Gutierrez-Gonzalez A, Najera-Ahumada AG, Cisneros-González N. Health and quality of life outcomes impairment of quality of life in type 2 diabetes mellitus: a cross-sectional study. Health Qual Life Outcomes. 2018;16:94.
Kalsekar ID, Madhavan SM, Amonkar MM, Scott V, Douglas SM, Makela E. The effect of depression on health care utilization and costs in patients with type 2 diabetes. Manag Care Interface. 2006;19:39–46.
Wu CS, Hsu LY, Wang SH. Association of depression and diabetes complications and mortality: a population-based cohort study. Epidemiol Psychiatr Sci. 2020;29: e96.
Perrin NE, Davies MJ, Robertson N, Snoek FJ, Khunti K. The prevalence of diabetes-specific emotional distress in people with type 2 diabetes: a systematic review and meta-analysis. Diabet Med. 2017;34:1508–20.
Owens-Gary MD, Zhang X, Jawanda S, Bullard KM, Allweiss P, Smith BD. The importance of addressing depression and diabetes distress in adults with type 2 diabetes. J Gen Intern Med. 2019;34:320–4.
Holt RI, de Groot M, Golden SH. Diabetes and depression. Curr Diab Rep. 2014;14:491.
https://www.researchforthefuture.org/registration-explained: Accessed 18 Mar 2022.
https://healthinnovationmanchester.com/thegmcarerecord/the-gm-care-record-for-secondary-uses-research: Accessed 28 Dec 2021.
https://digital.nhs.uk/services/summary-care-records-scr: Accessed 28 Dec 2021.
Rabin R, de Charro F. EQ-5D: a measure of health status from the EuroQoL Group. Ann Med. 2001;33:337–43.
Kroenke K, Spitzer RL, Williams JB, Löwe B. The patient health questionnaire somatic, anxiety, and depressive symptom scales: a systematic review. Gen Hosp Psychiatry. 2010;32:345–55.
Polonsky WH, Fisher L, Earles J, Dudl RJ, Lees J, Mullan J, Jackson RA. Assessing psychosocial distress in diabetes: development of the diabetes distress scale. Diabetes Care. 2005;28:626–31.
Beran M, Muzambi R, Geraets A, Albertorio-Diaz JR, Adriaanse MC, Iversen MM, Kokoszka A, Nefs G, Nouwen A, Pouwer F, Huber JW, Schmitt A, Schram MT, European Depression in Diabetes (EDID) Research Consortium. The bidirectional longitudinal association between depressive symptoms and HbA1c: a systematic review and meta-analysis. Diabet Med. 2022;39:e14671.
Ruissen MM, Regeer H, Landstra CP, Schroijen M, Jazet I, Nijhoff MF, Pijl H, Ballieux BEPB, Dekkers O, Huisman SD, de Koning EJP. Increased stress, weight gain and less exercise in relation to glycemic control in people with type 1 and type 2 diabetes during the COVID-19 pandemic. BMJ Open Diabetes Res Care. 2021;9: e002035.
Yu JT, Xu W, Tan CC, Andrieu S, Suckling J, Evangelou E, Pan A, Zhang C, Jia J, Feng L, Kua EH, Wang YJ, Wang HF, Tan MS, Li JQ, Hou XH, Wan Y, Tan L, Mok V, Tan L, Dong Q, Touchon J, Gauthier S, Aisen PS, Vellas B. Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials. J Neurol Neurosurg Psychiatry. 2020;91(11):1201–9.
Semenkovich K, Brown ME, Svrakic DM, Lustman PJ. Depression in type 2 diabetes mellitus: prevalence, impact, and treatment. Drugs. 2015;75:577–87.
Almeida OP, McCaul K, Hankey GJ, Yeap BB, Golledge J, Norman PE, Flicker L. Duration of diabetes and its association with depression in later life: the Health In Men Study (HIMS). Maturitas. 2016;86:3–9.
Griadil TI, Chopey IV, Chubirko KI. Peculiarities of diagnostics of depressions and clinical manifestations in patients with obesity and concomitant type 2 diabetes mellitus. Wiad Lek. 2019;72:519–22.
Sevilla-González MDR, Quintana-Mendoza BM, Aguilar-Salinas CA. Interaction between depression, obesity, and type 2 diabetes: a complex picture. Arch Med Res. 2017;48:582–91.
Hippisley-Cox J, Coupland CA, Mehta N, Keogh RH, Diaz-Ordaz K, Khunti K, Lyons RA, Kee F, Sheikh A, Rahman S, Valabhji J, Harrison EM, Sellen P, Haq N, Semple MG, Johnson PWM, Hayward A, Nguyen-Van-Tam JS. Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study. BMJ. 2021;374: n2244.
Heald AH, Jenkins DA, Williams R, Sperrin M, Fachim H, Mudaliar RN, Syed A, Naseem A, Gibson JM, Bowden Davies KA, Peek N, Anderson SG, Peng Y, Ollier W. The Risk factors potentially influencing hospital admission in people with diabetes, following SARS-CoV-2 infection: a population-level analysis. Diabetes Ther. 2022;24:1–15.
Heald AH, Jenkins DA, Williams R, Sperrin M, Mudaliar RN, Syed A, Naseem A, Bowden Davies KA, Peng Y, Peek N, Ollier W, Anderson SG, Delanerolle G, Gibson JM. Mortality in people with type 2 diabetes following SARS-COV-2 infection: a population level analysis of potential risk factors. Diabetes Ther. 2022;13:1–15. https://doi.org/10.1007/s13300-022-01259-3.
Stedman M, Lunt M, Davies M, Gibson M, Heald A. COVID-19: generate and apply local modelled transmission and morbidity effects to provide an estimate of the variation in overall relative healthcare resource impact at general practice granularity. Int J Clin Pract. 2020;74: e13533.
Holland D, Heald AH, Stedman M, Hanna F, Wu P, Duff C, Green L, Robinson S, Halsall I, Gaskell N, Pemberton J, Bloor C, Fryer AA. Assessment of the effect of the COVID-19 pandemic on UK HbA1c testing: implications for diabetes management and diagnosis. J Clin Pathol. 2021;13:jclinpath-2021-207776.
Carr MJ, Wright AK, Leelarathna L, Thabit H, Milne N, Kanumilli N, Ashcroft DM, Rutter MK. Impact of COVID-19 restrictions on diabetes health checks and prescribing for people with type 2 diabetes: a UK-wide cohort study involving 618,161 people in primary care. BMJ Qual Saf. 2021;12:bmjqs-2021-013613.
Stedman M, Rea R, Duff CJ, Livingston M, Brown S, Grady K, McLoughlin K, Gadsby R, Paisley A, Fryer AA, Heald AH. Self-reported views on managing type 1 diabetes mellitus. J Diabetes Sci Technol. 2021;15:198–200.
Stedman M, Rea R, Duff CJ, Livingston M, McLoughlin K, Wong L, Brown S, Grady K, Gadsby R, Gibson JM, Paisley A, Fryer AA, Heald AH. The experience of blood glucose monitoring in people with type 2 diabetes mellitus (T2DM). Endocrinol Diabetes Metab. 2022;5: e00302.
https://www.diabetes.org.uk/professionals/resources/national-diabetes-audit/nda-reports: accessed 24 Mar 2022.
Acknowledgements
Funding
The authors received no funding from an external source. The co-authors funded the journal’s Rapid Service Fee.
Author Contributions
All authors contributed equally and substantially to the co-creation and writing of this paper.
Disclosures
All authors confirm that they have no conflicts of interest.
Compliance with Ethics Guidelines
The survey was conducted online in late 2020 and early 2021 at the time of the COVID-19 global pandemic. Ethical approval was obtained from the Greater Manchester West Research Ethics Committee, REC reference 20/NW/0252. Informed consent was obtained from all participants.
Data Availability
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
About this article
Cite this article
Waheed, U., Heald, A.H., Stedman, M. et al. Distress and Living with Diabetes: Defining Characteristics Through an Online Survey. Diabetes Ther 13, 1585–1597 (2022). https://doi.org/10.1007/s13300-022-01291-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13300-022-01291-3