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Long non-coding RNA functions in lung cancer

  • Review
  • Published:
Tumor Biology

Abstract

Numerous long non-coding RNAs (lncRNAs) have been discovered as a result of advances in sequencing methods in genomic research. Recent evidence indicates that lncRNAs may serve as gene regulators via various mechanisms, such as translational control. Dysregulation of lncRNAs contributes to the development and progression of several human diseases, notably lung cancer, which is one of the leading causes of cancer-associated death. Recent studies have identified key roles for molecules such as p53 and polycomb repressive complex 2 (PRC2) in carcinogenesis and the anti-carcinogenic action of lncRNAs. These findings point to the potential of lncRNAs as prospective diagnostic and prognostic biomarkers in lung cancer. In this review, we consider the functions of lncRNAs in translational control and discuss their involvement in lung cancer via p53, PRC2, and other pathways. We also consider the effects of modulating the levels and functions of lncRNAs. Further characterization of these lung cancer-associated lncRNAs will provide a better understanding of their potential roles as therapeutic targets.

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Acknowledgments

This study was supported by grants from the National Natural Science Foundation of China (Grant number 81172786) and Youth Chenguang project of Science and Technology of Wuhan City (Grant number 201050231077).

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Authors and Affiliations

  1. Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jie Fang Avenue, Wuhan, 430030, Hubei, China

    Haiwei Sang, Peng Xiong & Min Zhu

  2. Department of Emergency Surgery, Affiliated Anhui Provincial Hospital, Anhui Medical University, No. 17, Lujiang Road, Hefei, 230001, Anhui, China

    Haihong Liu

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  1. Haiwei Sang
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  2. Haihong Liu
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  3. Peng Xiong
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  4. Min Zhu
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Correspondence to Min Zhu.

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Sang, H., Liu, H., Xiong, P. et al. Long non-coding RNA functions in lung cancer. Tumor Biol. 36, 4027–4037 (2015). https://doi.org/10.1007/s13277-015-3449-4

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  • DOI: https://doi.org/10.1007/s13277-015-3449-4

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