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SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway

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Tumor Biology

Abstract

Sex-determining region Y (SRY)-box protein 1 (SOX 1) has been reported to have the inhibiting effects on various cancer cells; however, the expression and effect of SOX 1 on laryngeal squamous cell carcinoma (LSCC) have not been determined. Therefore, the aim of this study was to assess the anti-proliferation and metastatic effects of SOX 1 and its related mechanisms on LSCC. According to our present study, first, we found that overexpression of SOX 1 could significantly inhibit proliferation and promote apoptosis in Tu212 cells. Additionally, overexpression of SOX 1 suppressed the migration and invasion potential of Tu212 cells via regulating Wnt/β-catenin pathway. Finally, we demonstrated for the first time that overexpression of SOX 1 could downregulate the expression of SOX 2, and co-expression of SOX 1 and SOX 2 could reverse the anti-tumor effect of SOX 1. In conclusion, our studies suggested that SOX 1 suppressed cell growth and invasion in Tu212 cells by inhibiting Wnt/β-catenin pathway, and the anti-tumor effect of SOX 1 could be weakened by SOX 2, which may be a potential molecular basis for clinical treatment of LSCC.

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Acknowledgments

This study was supported by a grant from the Natural Science Foundation of Liaoning Province (No.: 201202287).

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Authors and Affiliations

  1. Department of Otorhinolaryngology, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Shenyang, 110001, China

    Ning Yang, Yan Wang, Lian Hui, Xiaotian Li & Xuejun Jiang

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  1. Ning Yang
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  2. Yan Wang
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  3. Lian Hui
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  4. Xiaotian Li
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  5. Xuejun Jiang
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Correspondence to Ning Yang.

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Yang, N., Wang, Y., Hui, L. et al. SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/β-catenin pathway. Tumor Biol. 36, 8625–8635 (2015). https://doi.org/10.1007/s13277-015-3389-z

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  • DOI: https://doi.org/10.1007/s13277-015-3389-z

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