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Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

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Tumor Biology

Abstract

Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1, GSTT1, and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. The results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher’s exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed (χ 2 = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.

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Acknowledgements

This work was supported by grants of CAPES and CNPq. The authors would like to thank James overall for proofreading the article.

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Authors and Affiliations

  1. Graduate Program in Cellular and Molecular Biology and Laboratory of Structural Molecular Biology and Oncogenetics—LBMEO, Department of Molecular Biology, Federal University of Paraíba UFPB, 58051-900, Joao Pessoa, Paraiba, Brazil

    Rubistenia Miranda Soares de Araújo, Cynthia Farias Vieira de Melo & Juarez Nóbrega da Silva

  2. Laboratory of Structural Molecular Biology and Oncogenetics—LBMEO, Department of Molecular Biology, CCEN, Federal University of Paraíba UFPB, s/n, 58051-900, João Pessoa, Paraiba, Brazil

    Eleonidas Moura Lima

  3. Department of Medicine, Federal University of Paraíba UFPB, 58051-900, Joao Pessoa, Paraiba, Brazil

    Arnaldo Correia de Medeiros

  4. Department of Gastroenterology, Hospital São Marcos, 64001-280, Teresina, Piaui, Brazil

    Fidelis Manes Neto & Edilson Carvalho Sousa Jr.

  5. Department of Pharmacy, State University of Paraíba UEPB, 58429-500, Campina Grande, Paraiba, Brazil

    Leonardo Ferreira Soares

  6. Department of Morphology and Genetics, Federal University of São Paulo, 04023-900, Sao Paulo, Sao Paulo, Brazil

    Marilia de Arruda Cardoso Smith

  7. Department of Biology, Center of Biological Sciences, Federal University of Pará, 66075-110, Belem, Para, Brazil

    Rommel Mario Rodríguez Burbano

Authors
  1. Rubistenia Miranda Soares de Araújo
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  2. Cynthia Farias Vieira de Melo
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  3. Fidelis Manes Neto
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  4. Juarez Nóbrega da Silva
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  6. Marilia de Arruda Cardoso Smith
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  8. Rommel Mario Rodríguez Burbano
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  9. Arnaldo Correia de Medeiros
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  10. Eleonidas Moura Lima
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Correspondence to Eleonidas Moura Lima.

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de Araújo, R.M.S., de Melo, C.F.V., Neto, F.M. et al. Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil. Tumor Biol. 35, 4983–4986 (2014). https://doi.org/10.1007/s13277-014-1656-z

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  • DOI: https://doi.org/10.1007/s13277-014-1656-z

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