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A randomized clinical trial of nerve block to manage end-stage pancreatic cancerous pain

  • Research Article
  • Published:
Tumor Biology

Abstract

Pain control is the most difficult puzzle in patients with terminal pancreatic cancerous pain. Many methods in clinical practice fail in 20 ~ 50 % of patients. The present study aims to explore the effect of nerve block on patients with end-stage pancreatic cancerous pain. In this study, 100 subjects with end-stage pancreatic cancerous pain were enrolled and randomly assigned into two groups: 68 in nerve block group (N) and 32 in sham group (S). One group was treated with nerve block and the other group with sham procedure as controls. The pain score (by visual analog scale (VAS)), pain duration, reduction of other analgesic medications, and quality of life (with questionnaire QLQ) were evaluated before and 3 months after interventions. Comparisons were performed between before and after intervention in nerve block group and sham group. The results indicated that compared with sham group, the subjects in nerve block group had significant reduction with pain score, pain duration, and other analgesic medications, as well as improvement of quality of life (P < 0.05, respectively). In conclusion, nerve block is an effective method for treating patients with end-stage pancreatic cancerous pain.

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Acknowledgments

The present study was supported by the Post-Graduate Scientific Research Innovation Project of Education Department of Jiangsu Province (CXZZ12_0842), China; the open fund of the Stem Cell and Biomedical Material Key Laboratory of Jiangsu Province (KJS1230), China; Science and Technology Research Project of Science, and Technology Bureau of Suzhou City (SYS201330), China.

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Authors and Affiliations

  1. Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China

    Ling Gao, Jin Zhou, Yun-liang Wang & De-chun Li

  2. Department of Oncology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, China

    Yi-jin Yang & Hai-yan Xu

  3. Department of General Surgery, The East District of Suzhou Municipal Hospital, No. 16 Baita Road, 215000, Suzhou, China

    Han Hong

Authors
  1. Ling Gao
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  2. Yi-jin Yang
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  3. Hai-yan Xu
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  4. Jin Zhou
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  5. Han Hong
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  6. Yun-liang Wang
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  7. De-chun Li
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Corresponding author

Correspondence to Han Hong.

Additional information

Ling Gao, Yi-jin Yang, Hai-yan Xu, and Jin Zhou contributed equally to this work.

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Gao, L., Yang, Yj., Xu, Hy. et al. A randomized clinical trial of nerve block to manage end-stage pancreatic cancerous pain. Tumor Biol. 35, 2297–2301 (2014). https://doi.org/10.1007/s13277-013-1304-z

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  • DOI: https://doi.org/10.1007/s13277-013-1304-z

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