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RETRACTED ARTICLE: MicroRNA-128 promotes proliferation in osteosarcoma cells by downregulating PTEN

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Tumor Biology

This article was retracted on 20 April 2017

Abstract

MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators through targeting mRNAs for translational repression or degradation. Several studies have indicated that abnormal expression of miRNAs occurs frequently in human osteosarcoma. In the present study, we found that miR-128 expression was significantly increased in osteosarcoma tissues compared to adjacent normal tissues. Ectopic overexpression of miR-128 significantly promoted while suppression of miR-128 by its antisense inhibited the proliferation of MG63 and U2OS cells. At the molecular level, our results demonstrated that miR-128 overexpression could repress expression of PTEN by directly targeting PTEN 3'-untranslated region. Consistently, downstream AKT signaling was altered by miR-128 overexpression or knockdown. Therefore, our results suggest that miR-128 plays an important role in the proliferation of human osteosarcoma cells by directly regulation of PTEN/AKT signaling.

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Acknowledgments

This work was partially supported by National natural science foundation 81171705.

Conflict of interest

The authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Xinhua Hospital, Shanghai JiaoTong University School of Medicine, No.1665 kongjiang Rd., Shanghai, 200092, People’s Republic of China

    Lei Shen, Xiao-Dong Chen & Yao-Hui Zhang

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  1. Lei Shen
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  2. Xiao-Dong Chen
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  3. Yao-Hui Zhang
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Corresponding authors

Correspondence to Xiao-Dong Chen or Yao-Hui Zhang.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

An erratum to this article can be found online at http://dx.doi.org/10.1007/s13277-017-5487-6.

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Shen, L., Chen, XD. & Zhang, YH. RETRACTED ARTICLE: MicroRNA-128 promotes proliferation in osteosarcoma cells by downregulating PTEN. Tumor Biol. 35, 2069–2074 (2014). https://doi.org/10.1007/s13277-013-1274-1

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  • DOI: https://doi.org/10.1007/s13277-013-1274-1

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