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Association between IL-4 -590C>T polymorphism and gastric cancer risk

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Tumor Biology

Abstract

Published studies on the association between interleukin-4 (IL-4) -590C>T polymorphism and gastric cancer risk have yielded conflicting results. Thus, a meta-analysis of published studies was performed to assess the possible association. All eligible studies of -590C>T polymorphism and gastric cancer risk were collected from the PubMed, the Cochrane Library, and the Embase electronic databases. Statistical analyses were performed by Review Manager 5.0 and Stata 11.0. When all groups were pooled, we did not detect a significant association of -590C>T polymorphism with gastric cancer risk. When stratifying for race, there was a significant association between -590C>T polymorphism and decreased gastric cancer risk under dominant model and allelic model in the subgroup of Caucasians. However, significant association was absent in Asians. Based on our meta-analysis, -590C>T polymorphism was associated with a lower gastric cancer risk under dominant model and allelic model in Caucasians. Nevertheless, we suggest that further studies should be made to confirm these findings.

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Authors and Affiliations

  1. Department of laboratory diagnosis, General Hospital of Jinan Military Region, Shandong, China

    Zihan Sun

  2. Department of Prevention and Health Care District 3, Centers for Disease Control and Prevention, Jinan Military Region, Shandong, China

    Yuling Cui & Jing Pei

  3. Department of Health District 3, General Hospital of Jinan Military Region, 25 Shifan Road, Tianqiao District, Shandong, 250031, China

    Xiaohong Jin & Jing Pei

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  1. Zihan Sun
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  2. Yuling Cui
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  3. Xiaohong Jin
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  4. Jing Pei
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Corresponding author

Correspondence to Jing Pei.

Additional information

Zihan Sun and Yuling Cui contributed equally to this work.

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Sun, Z., Cui, Y., Jin, X. et al. Association between IL-4 -590C>T polymorphism and gastric cancer risk. Tumor Biol. 35, 1517–1521 (2014). https://doi.org/10.1007/s13277-013-1209-x

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  • DOI: https://doi.org/10.1007/s13277-013-1209-x

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