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Lack of association of genetic polymorphisms of angiotensin converting enzyme 1 and angiotensin II type 1 receptor with breast cancer risk in Iranian population

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Tumor Biology

Abstract

We aimed to investigate the association of insertion/deletion (I/D) and A1166C polymorphisms of angiotensin I converting enzyme 1 and angiotensin II type 1 receptor genes, respectively and their combination on breast cancer risk in an Iranian population. A case–control study (70 cases, 70 controls) was performed on an Iranian population. The I/D and A1166C polymorphisms were analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism PCR, respectively. The results revealed no significant difference between cases and controls in I/D (p = 0.14) and A1166C (p = 0.94) polymorphisms after adjustment for breast cancer known risk factors. In combined genotype analysis, considering DD and AA genotypes as low-risk genotypes, women with one and two high-risk genotypes (one high-risk genotype: adjusted odds ratio (OR), 1.24; two high-risk genotypes: adjusted OR, 1.97) were at higher risk for breast cancer. Also, the highest risk for breast cancer was seen in a subgroup of postmenopausal women carriers of two high-risk genotypes (adjusted OR, 2.41). In conclusion, I/D and A1166C polymorphisms are not significantly associated with breast cancer risk in the Iranian population; however, the combination of these two polymorphisms seems to have a synergic effect on the risk of breast cancer particularly in postmenopausal women, which may deserve consideration in large-scale case–control studies.

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Acknowledgments

We would like to express our gratitude to Dr. Talei at Shahid Faghihi Hospital, Shiraz, Iran for providing samples and clinical information. We also greatly thank Ms. Valibeigi for her technical assistance in genotyping the samples. We would like to acknowledge the Clinical Research Development Center for giving helpful comments on data analysis.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, 71345-1583, Iran

    Soha Namazi & Shirin Ardeshir-Rouhani-Fard

  2. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, 71344-1864, Iran

    Ahmad Monabati

  3. Organ Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, 71937-11351, Iran

    Negar Azarpira

  4. Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, P.O. Box: 71345–1583, Shiraz, Iran

    Shirin Ardeshir-Rouhani-Fard

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  1. Soha Namazi
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Correspondence to Shirin Ardeshir-Rouhani-Fard.

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Namazi, S., Monabati, A., Ardeshir-Rouhani-Fard, S. et al. Lack of association of genetic polymorphisms of angiotensin converting enzyme 1 and angiotensin II type 1 receptor with breast cancer risk in Iranian population. Tumor Biol. 34, 2899–2907 (2013). https://doi.org/10.1007/s13277-013-0852-6

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  • DOI: https://doi.org/10.1007/s13277-013-0852-6

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