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Is there a relationship between PPARD T294C/PPARGC1A Gly482Ser variations and physical endurance performance in the Korean population?

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Abstract

The peroxisome proliferator-activated receptor δ (PPARD) and peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A) genes recently have been suggested to have an association with athletic performance and physical endurance. These gene products are reported to be crucial components in training-induced muscle adaptation, since they are related with mRNA and/or protein activity in coordinated response to exercise. To assess the possible contribution of the PPARD T294C/PPARGC1A Gly482Ser polymorphism to differences in physical endurance, we performed a population-based study of 111 Korean athletes and 145 healthy controls based on their genotype distribution of the genes. The two loci were found to be not deviated from Hardy–Weinberg equilibrium. There were no differences in genotype distribution of PPARD T294C and PPARGC1A Gly482Ser between the athletic group and controls (p > 0.05). In contrast, we found a significant association between the PPARGC1A Gly482Ser polymorphism and the 20 m shuttle run activity (a measure of endurance performance) in the athletic group (p = 0.003). The result showed a remarkable increase in the numbers of shuttle run ratio from subjects with the PPARGC1A Gly/Gly genotype (85.29 ± 28.80) than those with the Gly/Ser (58.05 ± 32.76) and Ser/Ser (68.38 ± 30.47) genotypes. Thus, our data imply that the PPARGC1A Gly/Gly genotype may provide a beneficial effect on elite-level endurance status, although functional studies with larger sample sizes are necessary to elucidate these findings.

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Acknowledgments

We are grateful to all volunteers for providing DNA samples. This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (NRF-2014S1A5B6037521). This work was also supported in part by DANKOOK ChemBio Specialization for Creative Korea-II (2015).

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Authors and Affiliations

  1. Department of Nanobiomedical Science, Dankook University, Cheonan, 330-714, Republic of Korea

    Han-Jun Jin, In-Wook Hwang, Ye-Eun Shin & Ji-Yeon Lee

  2. Department of Biological Sciences, Dankook University, Cheonan, 330-714, Republic of Korea

    Ki-Cheol Kim, Kwang-Hee Lee, Ji-Ae Kim, Eun-Ji Choi, Bo-Kyeong Kim, Hee-Seob Sim & Wook Kim

  3. Department of Sports Management, Dankook University, Cheonan, 330-714, Republic of Korea

    Hyun-Ik Cho & Tae-Hwan Park

  4. Department of Kinesiology and Medical Science, Dankook University, Cheonan, 330-714, Republic of Korea

    Yun-A Shin, Ho-Seong Lee, Ji-Hyun Hwang, Ah-Ram Kim & Min-Seok Kim

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  1. Han-Jun Jin
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Correspondence to Wook Kim.

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The study was approved by the Ethics Committee and Institutional Review Board of Dankook University, Korea.

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Jin, HJ., Hwang, IW., Kim, KC. et al. Is there a relationship between PPARD T294C/PPARGC1A Gly482Ser variations and physical endurance performance in the Korean population?. Genes Genom 38, 389–395 (2016). https://doi.org/10.1007/s13258-015-0380-4

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