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Poly-l-lactide Polymer-Based Triple Drug-Eluting Stent with Abciximab, Alpha-Lipoic Acid and Sirolimus in Porcine Coronary Restenosis Model

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Abstract

This study evaluated the effect of a novel triple drug-eluting stent containing antithrombotic abciximab, antioxidative alpha-lipoic acid (ALA), and antiproliferative sirolimus in a porcine model. The coronary arteries of pigs were randomized into three groups: triple drug-eluting stent (TES; n=10), sirolimus-eluting stent (SES; n=10), and bare metal stent (BMS; n=10). At 28 days after stent implantation, a histopathologic analysis was performed. There were no significant differences in the injury score. There were significant differences in the neointimal area (2.3±0.6 mm2 in TES vs. 2.5±0.88 mm2 in SES vs. 3.3±0.58 mm2 in BMS, p<0.0001), percent area of stenosis (37.1±9.26% in TES vs. 46.1±15.9% in SES vs. 66.2±10.12% in BMS, p<0.0001), inflammation score (1.0 [range, 0.0-1.0] in TES vs. 1.5 [range, 1.0-2.0] in SES vs. 1.0 [range, 1.0-2.0] in BMS, p<0.05), and fibrin score (2.0 [range, 1.0-2.0] in TES vs. 2.0 [range, 1.0-2.5] in SES vs. 0.0 [range, 0.0-1.0] in BMS, p<0.0001) among the three groups. The occlusion rates using micro-computed tomography showed similar restenosis rates based on histologic analysis (35.4±8.39% in TES vs. 43.4±10.12% in SES vs. 71.4±4.38% in BMS, p<0.0001). TES demonstrated an inhibitory effect on the smooth muscle cells compared to the other stents. It also suppressed inflammation in the stented lesion compared to SES as evidenced by the inflammation score.

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Author notes

  1. These authors contributed equally to this work.

Authors and Affiliations

  1. CGBio Co. Ltd, Jangseong, 14722, Korea

    Jun-Kyu Park

  2. Department of Internal Medicine and Cardiovascular Center, Chosun University Hospital, University of Chosun College of Medicine, Gwangju, 61453, Korea

    Sung Soo Kim & Hyun Kuk Kim

  3. Department of Polymer Science and Engineering, Sunchon National University, Suncheon, 57922, Korea

    Jae-Woon Nah, Doo Sun Sim, Young Joon Hong & Myung Ho Jeong

  4. Cardiovascular Research Center, Chonnam National University Hospital, Gwangju, 61469, Korea

    Han Byul Kim, In Ho Bae, Dae Sung Park, Jae Won Shim & Myung Ho Jeong

  5. Korea Cardiovascular Stent Research Institute, Jangsung, 57248, Korea

    In Ho Bae, Dae Sung Park & Jae Won Shim

  6. Cardiovascular Convergence Research Center of Chonnam National University Hospital Designated by Korea Ministry of Health and Welfare, Gwangju, 61469, Korea

    In Ho Bae, Dae Sung Park, Jae Won Shim, Doo Sun Sim & Myung Ho Jeong

  7. Research Institute of Medical Sciences, Chonnam National University, Gwangju, 61186, Korea

    Dae Sung Park

  8. College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, Korea

    Min Young Lee

  9. Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, Korea

    Joong Sun Kim

  10. Futuristic Animal Resource and Research Center & National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang 28116, Chungbuk, Korea

    Bon-Sang Koo, Kang-Jin Jeong, Yeong Bae Jin, Sun-Uk Kim, Sang-Rae Lee & Kyung Seob Lim

  11. Biomedical Research Institute, Chonnam National University Hospital, Gwangju, 61469, Korea

    Joo-Young Na

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  1. Jun-Kyu Park
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Correspondence to Kyung Seob Lim or Myung Ho Jeong.

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Acknowledgments: This study was supported by grants from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (NRF-2017R1C1B1001956) as well as the Korea Research Institute of Bioscience and Biotechnology Research Initiative Program (KGM4251824), Republic of Korea.

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Park, JK., Kim, S.S., Kim, H.K. et al. Poly-l-lactide Polymer-Based Triple Drug-Eluting Stent with Abciximab, Alpha-Lipoic Acid and Sirolimus in Porcine Coronary Restenosis Model. Macromol. Res. 28, 9–14 (2020). https://doi.org/10.1007/s13233-020-8004-5

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