Skip to main content
SpringerLink
Log in

A novel hybrid polyhedral oligomeric silsesquioxane-based copolymer with zwitterion: Synthesis, characterization, self-assembly behavior and pH responsive property

  • Article
  • Published:
Macromolecular Research Aims and scope Submit manuscript

Abstract

A novel zwitterionic hybrid amphiphilic copolymer containing polyhedral oligomericsilsesquioxane (POSS), and poly(methacrylate isobutyl POSS)-b-poly (3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonaten-co-2-(diethylamino) ethyl methacrylate-co-styrene) (PMAiBuPOSS-b-P(DMAPS-co-DMAEMA-co-St)), was prepared by the ring open reaction of 1, 3-propane sultone with tertiary amine on the precursor polymer. This hybrid copolymer could self-assemble into spherical micelle with a relatively narrow size distribution. The micelle size exhibited a great dependence on pH, as the size of the micelles was of evidently decreases with the increase of the pH value. Controllable release of pyrene from the micelles was investigated by fluorescent emission spectra. Micelles with more zwitterionic units would lead to less pyrene release and longer equilibrium time. The protein adsorption resistance of the micelles was tested by mixing them with fetal bovine serum. The antifouling ability was improved by increasing the number of zwitterionic units as well as decreasing the number of DMAEMA units. This novel hybrid amphiphilic random copolymer with the pH-responsive and anti-protein-fouling ability, can be potentially used for drug carriers for controlled release.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. H. G. Schild, Prog. Polym. Sci., 17, 163 (1992).

    Article  CAS  Google Scholar 

  2. J. Rodriguez-Hernandez, F. Chécot, Y. Gnanou, and S. Lecommandoux, Prog. Polym. Sci., 30, 691 (2005).

    Article  CAS  Google Scholar 

  3. S. Ganta, H. Devalapally, A. Shahiwala, and M. Amiji, J. Control. Release, 126, 187 (2008).

    Article  CAS  Google Scholar 

  4. D. Roy, J. N. Cambre, and B. S. Sumerlin, Prog. Polym. Sci., 35, 278 (2010).

    Article  CAS  Google Scholar 

  5. S. Wu, Q. J. Zhang, and C. Bubeck, Macromolecules, 43, 6142 (2010).

    Article  CAS  Google Scholar 

  6. J. Lee, H. Yang, C. H. Park, H. H. Cho, H. Yun, and B. J. Kim, Chem. Mater., 28, 3446 (2016).

    Article  CAS  Google Scholar 

  7. C. H. Park, H. Yun, H. Yang, J. Lee, and B. J. Kim, Adv. Funct. Mater., 27, 1604403 (2017).

    Article  Google Scholar 

  8. C. H. Park, H. Yang, J. Lee, H. H. Cho, D. Kim, D. C. Lee, and B. J. Kim, Chem. Mater., 27, 5288 (2015).

    Article  CAS  Google Scholar 

  9. H. J. Niu, L. W. Zhang, M. Y. Gao, and Y. M. Chen, Langmuir, 21, 4205 (2005).

    Article  CAS  Google Scholar 

  10. C. M. Schilli, M. F. Zhang, E. Rizzardo, S. H. Thang, Y. K. Chong, K. Edwards, G. Karlsson, and A. H. Müller, Macromolecules, 37, 7861 (2004).

    Article  CAS  Google Scholar 

  11. W. Wu, W. G. Wang, S. Li, J. T. Wang, Q. J. Zhang, X. H. Li, X. L. Luo, and J. S. Li, J. Polym. Res., 21, 494 (2014).

    Article  Google Scholar 

  12. X. Z. Jiang, J. Y. Zhang, Y. M. Zhou, J. Xu, and S. Liu, J. Polym. Sci., Part A: Polym. Chem., 46, 860 (2008).

    Article  CAS  Google Scholar 

  13. Y. H. Liu, X. H. Cao, M. B. Luo, Z. G. Le, and W. Y. Xu, J. Colloid Interface Sci., 329, 244 (2009).

    Article  CAS  Google Scholar 

  14. M. Vamvakaki, D. Palioura, A. Spyros, S. P. Armes, and S. H. Anastasiadis, Macromolecules, 39, 5106 (2006).

    Article  CAS  Google Scholar 

  15. Y. Q. Yang, W. J. Lin, L. J. Zhang, C. Z. Cai, and W. Jiang, Macromol. Res., 21, 1101 (2013).

    Google Scholar 

  16. K. H. Kim, J. Kim, and W. H. Jo, Polymer, 46, 2836 (2005).

    Article  CAS  Google Scholar 

  17. L. Zheng, A. J. Waddon, R. J. Farris, and E. B. Coughlin, Macromolecules, 35, 2375 (2002).

    Article  CAS  Google Scholar 

  18. L. Liu, M. Tian, W. Zhang, L. Zhang, and J. E. Mark, Polymer, 48, 3201 (2007).

    Article  CAS  Google Scholar 

  19. D. Zhang, G. S. Huang, Y. H. Shi, G. Y. Zhang, and Y. F. Liu, J. Appl. Polym. Sci., 132, (2015).

    Google Scholar 

  20. H. Liu, and S. Zheng, Macromol. Rapid Commun., 26, 196 (2005).

    Article  Google Scholar 

  21. J. P. Lewicki, K. Pielichowski, M. Jancia, E. Hebda, R. F. Alob, and R. S. Maxwell, Polym. Degrad. Stabil., 104, 50 (2014).

    Article  CAS  Google Scholar 

  22. J. K. Lam, Y. Ma, S. P. Armes, A. L. Lewis, T. Baldwin, and S. Stolnik, J. Control. Release, 100, 293 (2004).

    Article  CAS  Google Scholar 

  23. C. Pegoraro, D. Cecchin, L. S. Gracia, N. Warren, J. Madsen, S. P. Armes, A. Lewis, S. Macneil, and G. Battaglia, Cancer Lett., 334, 328 (2013).

    Article  CAS  Google Scholar 

  24. Z. Q. Cao, Q. M. Yu, H. Xue, G. Cheng, and S. Y. Jiang, Angew. Chem. Int. Ed., 49, 3771 (2010).

    Article  CAS  Google Scholar 

  25. Z. Q. Cao, and S. Y. Jiang, Nano Today, 7, 404 (2012).

    Article  CAS  Google Scholar 

  26. L. Zhang, H. Xue, Z. Q. Cao, A. Keefe, J. N. Wang, and S. Y. Jiang, Biomaterials, 32, 4604 (2011).

    Article  CAS  Google Scholar 

  27. F. Y. Dai and W. G. Liu, Biomaterials, 32, 628 (2011).

    Article  CAS  Google Scholar 

  28. Y. J. Shih, Y. Chang, A. Deratani, and D. Quemener, Biomacromolecules, 13, 2849 (2012).

    Article  CAS  Google Scholar 

  29. J. Chiefari, Y. K. Chong, F. Ercole, J. Krstina, J. Jeffery, T. P Le, R. A. Mayadunne, G. F. Meijs, C. L. Moad, G. Moad, E. RIzzardo, and Z. H. Thang, Macromolecules, 31, 5559 (1998).

    Article  CAS  Google Scholar 

  30. Y. J. Liu, B. Liu, and Z. H. Nie, Nano Today, 10, 278 (2015).

    Article  CAS  Google Scholar 

  31. M. A. Taleb, Int. J. Biol. Macromol., 62, 341 (2013).

    Article  Google Scholar 

  32. M. J. Bruininga, H. G. T. Blaauwgeersb, R. Kuijera, E. Pelsc, R. M. M. A. Nuijtsb, and L. H. Koolea, Biomaterials, 21, 595 (2000).

    Article  Google Scholar 

  33. D. J. Liaw, W. F. Lee, Y. C. Whung, and M. C. Lin, J. Appl. Polym. Sci., 34, 999 (1987).

    Article  CAS  Google Scholar 

  34. Y. T. Li, B. S. Lokitz, S. P. Armes, and C. L. McCormick, Macromolecules, 8, 2726 (2006).

    Article  Google Scholar 

  35. Y. F. Zhu, J. L. Shi, W. H. Shen, X. P. Dong, J. W. Feng, M. L. Ruan, and Y. S. Li, Angew. Chem. Int. Ed., 117, 5213 (2005).

    Article  Google Scholar 

  36. S. Stefani, I. N. Kurniasih, S. K. Sharma, C. Böttcher, P. Servin, and R. Haag, Polym. Chem., 7, 887 (2016).

    Article  CAS  Google Scholar 

  37. M. Mertoglu, S. Garnier, A. Laschewsky, K. Skrabaniaa, and S. Joachim, Polymer, 46, 7726 (2005).

    Article  CAS  Google Scholar 

  38. S. Y. Jiang and Z. Q. Cao, Adv. Mater., 22, 920 (2010).

    Article  CAS  Google Scholar 

  39. L. Lartigue, C. Wilhelm, J. Servais, C. Factor, A. Dencausse, J. C. Bacri, N. Luciani, and F. Gazeau, ACS Nano, 6, 2665 (2012).

    Article  CAS  Google Scholar 

  40. S. Z. Luo, M. C. Han, Y. H. Cao, C. X. Ling, and Y. Y. Zhang, Colloid Polym. Sci., 289, 1243 (2011).

    Article  CAS  Google Scholar 

  41. Y. Arima and H. Iwata, Biomaterials, 28, 3074 (2007).

    Article  CAS  Google Scholar 

  42. D. S. Johnston, S. Sanghera, M. Pons, and D. Chapman, BBA-Biomembranes, 602, 57 (1980).

    Article  CAS  Google Scholar 

  43. A. Hasan and L. M. Pandey, Polym. Plast. Technol., 54, 1358 (2015).

    Article  CAS  Google Scholar 

  44. X. M. Yan, J. Kong, C. C. Yang, and G. Q. Fu, J. Colloid Interface Sci., 445, 9 (2015).

    Article  CAS  Google Scholar 

  45. H. Chen, L. Yuan, W. Song, Z. K. Wu, and D. Li, Prog. Polym. Sci., 33, 1059 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Fujian Provincial Key Laboratory of Fire Retardant Materials, College of Materials, Xiamen University, Xiamen, P. R. China

    Yiting Xu, Jiamei Huang, Yuntong Li, Meijie Wang, Ying Cao, Conghui Yuan, Birong Zeng & Lizong Dai

Authors
  1. Yiting Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiamei Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yuntong Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Meijie Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ying Cao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Conghui Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Birong Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Lizong Dai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yiting Xu.

Additional information

Acknowledgments: The authors acknowledge the National Natural Science Foundation of China (51273164) for funding. Financial support from Scientific and Technological Innovation Platform of Fujian Province (2014H2006) is also gratefully acknowledged.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xu, Y., Huang, J., Li, Y. et al. A novel hybrid polyhedral oligomeric silsesquioxane-based copolymer with zwitterion: Synthesis, characterization, self-assembly behavior and pH responsive property. Macromol. Res. 25, 817–825 (2017). https://doi.org/10.1007/s13233-017-5098-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13233-017-5098-5

Keywords

Search

Navigation