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Synthesis of poly(glycolide-caprolactone) copolymers for application as bioabsorbable suture materials

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Abstract

A novel bioabsorbable suture, poly(glycolide caprolactone) (PGLCL) copolymer, was synthesized by second step polymerization. The effect of the reaction parameters on the inherent viscosity of the PGLCL prepolymer was examined. The chemical structure of the copolymer was characterized by 1H nuclear magnetic resonance (NMR) and 13C NMR spectroscopy. The thermal properties of the copolymer were examined by differential scanning calorimetry and thermogravimetric analysis. Both the straight strength and knot strength of the PGLCL copolymer monofilament in vivo decreased significantly with increasing implant time. The organism resolvability tests confirmed that the PGLCL copolymer monofilament suture had been absorbed within 91 days with recovery from the inflammatory response. The biocompatibility tests indicated that all items had passed.

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Authors and Affiliations

  1. Department of Textile Engineering, Chonbuk National University, Jeonbuk, 560-756, Korea

    Yeon-Chun Yoo & Hak-Yong Kim

  2. School of Chemical and Materials Engineering, Jilin Institute of Chemical Technology, Jilin City, 132022, P. R. China

    Fan-Long Jin

  3. Department of Chemistry, Inha University, Nam-gu, Incheon, 402-751, Korea

    Soo-Jin Park

Authors
  1. Yeon-Chun Yoo
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  2. Hak-Yong Kim
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  3. Fan-Long Jin
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  4. Soo-Jin Park
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Correspondence to Hak-Yong Kim or Soo-Jin Park.

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Yoo, YC., Kim, HY., Jin, FL. et al. Synthesis of poly(glycolide-caprolactone) copolymers for application as bioabsorbable suture materials. Macromol. Res. 21, 687–692 (2013). https://doi.org/10.1007/s13233-013-1071-0

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  • DOI: https://doi.org/10.1007/s13233-013-1071-0

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