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Synthesis and properties of hyaluronic acid containing copolymers crosslinked by γ-ray irradiation

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Abstract

Biocompatible and biodegradable hydrogels based on polyvinylpyrrolidone (PVP), gelatin and hyaluronic acid (HA were prepared using a gamma irradiation polymerization technique, and their characteristics were examined. The degree of gelation for these systems was between 55–85% and increased with increasing gelatin or PVP content increased. The gel fraction of the HA/gelatin hydrogel was 30% larger than that of the HA/PVP hydrogel when exposed to a 30–50 kGy radiation dose. The increase in cross-linking density by gamma irradiation was confirmed by TGA. Swelling studies of the hydrogels prepared under various conditions were carried out in aqueous solutions ranging in pH from 2–8 to determine the pH sensitivity. The hydrogels based on HA had the highest swollen water content with a ratio of 1:10 (HA:gelatin and 1:5 (HA:PVP and a 30 kGy radiation dose. HA/gelatin gels showed a large swelling ratio at pH 2 and above pH 5, but the swelling ratio at pH 4 was relatively small. The difference in the swelling degree in various pH media was due to the formation of a polyelectrolyte complex containing oppositely charged polymers.

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Authors and Affiliations

  1. Radiation Research Division for Industry & Environment, Korea Atomic Energy Research Institute, Jeollabuk-do, 580-185, Korea

    Youn-Mook Lim, Hui-Jeong Gwon, Jong-Seok Park & Young-Chang Nho

  2. Fuel Gas Treatment Research Team, Clean Energy Research Department, Korea Institute of Energy Research, Daejeon, 305-343, Korea

    Jae-Woon Shim

  3. Department of Oral Biology & Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seou1, 130-701, Korea

    Il Keun Kwon & Sung-Eun Kim

  4. Department of Food Science and Human Nutrition, Chonbuk University, Jeollabuk-do, 561-756, Korea

    Sang-Ho Baik

Authors
  1. Youn-Mook Lim
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  2. Hui-Jeong Gwon
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  3. Jong-Seok Park
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  4. Young-Chang Nho
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  5. Jae-Woon Shim
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  6. Il Keun Kwon
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  7. Sung-Eun Kim
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  8. Sang-Ho Baik
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Correspondence to Young-Chang Nho.

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Lim, YM., Gwon, HJ., Park, JS. et al. Synthesis and properties of hyaluronic acid containing copolymers crosslinked by γ-ray irradiation. Macromol. Res. 19, 436–441 (2011). https://doi.org/10.1007/s13233-011-0513-9

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  • DOI: https://doi.org/10.1007/s13233-011-0513-9

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