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The Effect of Age and AMH Level on ART Outcomes in Patients With Reduced Ovarian Reserve: A Retrospective Cross-Sectional Study

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Abstract

Background

Despite many advances, patients with a poor ovarian response to stimulation are one of the most important and challenging factors of infertility. Chronological and ovarian ages are two effective factors responsible for poor response to assisted reproduction treatment. The purpose of this study was to determine the effect of age and AMH level on the in vitro fertilization (IVF) outcomes in participants with a reduced ovarian reserve.

Methods

In this retrospective cross-sectional study, 210 participants with anti-Mullerian hormone (AMH) < 1.1 ng/ml were included. The effect of age and AMH on pregnancy outcomes including dominant follicle count, serum estradiol level on the day of trigger administration, number of metaphase II (MII) oocytes, number of embryos, biochemical pregnancy, clinical pregnancy, abortion and live birth rate were evaluated.

Results

The number of dominant follicle (p < 0.001), MII oocyte (p < 0.001), grade A (p < 0.001) and B (p < 0.001) embryos, serum estradiol level (p < 0.001), gonadotropin level ( p< 0.001), AMH (p = 0.001), biochemical pregnancy (p = 0.007), clinical (p = 0.01) pregnancy, and live birth rate (p = 0.003) were higher in participants younger than 35 years old. In univariable logistic regression, the chance of retrieving more than 3 oocytes in individuals over 35 years old was 97.1% lower than in individuals younger than 35 years old (p < 0.001).

Conclusion

It has been concluded that the higher clinical pregnancy and live birth rate in participants younger than 35 years can be due to the higher AMH level in this group. Under the same conditions of AMH and other variables, age can affect the number of retrieved oocytes.

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Acknowledgments

The authors would like to thank the members of the Reproductive Health Research Center of Guilan University of Medical Sciences for their constant support.

Funding

This work was supported by Guilan University of Medical Sciences.

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Authors and Affiliations

  1. Reproductive Health Research Center, Department of Obstetrics & Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran

    Fatemeh Hosseinzadeh (Dr), Roya Kabodmehri (Dr), Mandana Mansour-Ghanaei (Dr), Ziba Zahiri Sorouri (Dr), Nasrin Ghanami Gashti (Dr) & Sakineh Hanifi (Dr)

  2. Mehr Fertility Research Center, Guilan University of Medical Sciences, Rasht, Iran

    Marzieh Mehrafza (Dr) & Ziba Zahiri Sorouri (Dr)

  3. Vice-Chancellorship of Research and Technology, Guilan University of Medical Science, Rasht, Iran

    Maryam Ghalandari (Vice-Chancellorship)

Authors
  1. Fatemeh Hosseinzadeh
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  2. Roya Kabodmehri
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  3. Marzieh Mehrafza
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  4. Mandana Mansour-Ghanaei
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  5. Ziba Zahiri Sorouri
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  6. Nasrin Ghanami Gashti
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  7. Sakineh Hanifi
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  8. Maryam Ghalandari
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Contributions

FH, RK., ZZS; Contributed to conception and design, data collection; NGG, and SH; Drafted the manuscript, which was revised by MM, and MMG; MG; statistical analysis; All authors read and approved the final manuscript.

Corresponding author

Correspondence to Roya Kabodmehri.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

Ethical approval was obtained from the ethics committee of Guilan University of Medical Sciences (approval id: IR.GUMS.REC.1399.130).

Informed consent

Informed consent was taken from all participants.

Human Participants

This research involved human participants. Ethical approval was obtained from the Ethics Committee of Guilan University of Medical Sciences (Approval ID: IR.GUMS.REC.1399.130). Informed consent has been obtained from all participants in adherence to the Declaration of Helsinki.

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Hosseinzadeh, F., Kabodmehri, R., Mehrafza, M. et al. The Effect of Age and AMH Level on ART Outcomes in Patients With Reduced Ovarian Reserve: A Retrospective Cross-Sectional Study. J Obstet Gynecol India 72, 420–425 (2022). https://doi.org/10.1007/s13224-021-01582-y

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  • DOI: https://doi.org/10.1007/s13224-021-01582-y

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