Abstract
Nano-anticancer drugs are gaining importance in cancer treatment due to their unique properties and wide range of applications. The efforts are made to synthesize silver nanoparticles by a green method and used as nano-carriers for curcumin. Green synthesis of the gum-stabilized AgNPs was monitored by UV–Vis spectrophotometry and the possible interactions of gum with AgNPs were evaluated by FT-IR. The curcumin-loaded AgNPs were characterized for their size, polydispersity index, ζ potential, morphology, size distribution, drug loading efficiency, and excipients’ interactions. The prepared nano-anticancer formulations were characterized and tested for anti-cancer potentials against MM-138, FM-55 and MCF-7 cell lines, respectively. The AgNPs acted as excellent nano-carriers for an increased amount of curcumin. In in vitro anticancer study, the IC50 values for AgNPs, curcumin, and curcumin-loaded AgNPs were 166.3, 82.2 and 61.6 µg/mL; 153.2, 107.3 and 77.1 µg/mL; and 144.6, 81.2 and 60.6 µg/mL against MM-138, FM-55 and MCF-7 cell lines, respectively. It was observed that silver nanoparticles showed good loading capacity for curcumin. Also, the curcumin-loaded nanoparticles showed good anticancer activities against MM-138, FM-55 and MCF-7 cell lines, respectively. The reported nano-anticancer drug formulations may be tested in vivo studies and clinical trials for treating cancer in the future.
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Acknowledgements
The present study was partially supported by the targeted grant from the University of Sharjah (grant no. 16010901011-P). The authors would like to thank the University of Science and Technology of Fujairah, Fujairah, UAE, and University of Sharjah, Sharjah (UAE) for their support and the research facilities provided. The authors are also grateful to Taif University Researchers Supporting Project number (TURSP-2020/44), Taif University, Taif, Saudi Arabia.
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Ali, I., Ahmed, S.B.M., Elhaj, B.M. et al. Enhanced anticancer activities of curcumin-loaded green gum acacia-based silver nanoparticles against melanoma and breast cancer cells. Appl Nanosci 11, 2679–2687 (2021). https://doi.org/10.1007/s13204-021-02176-w
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DOI: https://doi.org/10.1007/s13204-021-02176-w