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Expression of Epidermal Growth Factor Receptor (EGFR) and β-catenin in Colorectal Carcinoma and its Correlation with Tumor Grade and Stage

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Abstract

Colorectal cancer (CRC) is considered the result of the cumulative effect of multiple mutations within the cell that allow it to escape growth control and regulatory mechanisms. EGFR overexpression has been suggested as a factor of poor prognosis in various cancers. β-catenin plays a role in the Wnt signaling pathway of colorectal cancers. An analytical cross-sectional study was conducted over a period of two years comprising 20 colectomy specimens. Clinicopathological details were documented, and immunohistochemistry (IHC) for EGFR and β-catenin was performed. EGFR-Brown membranous staining was observed; β-catenin-Brown membranous or nuclear staining was observed. IHC scoring was done, taking into account the intensity of staining and the percentage of positive tumor cells. The mean age of patients with colorectal carcinoma was 47.45 ± 14.8 (mean + SD) years. No statistically significant difference was noted in the EGFR immunoexpression and tumor grade (p value = 0.361) as well as the TNM stage (p value = 0.699). There was no statistically significant difference between β-catenin immunoexpression and tumor grade (p value = 0.444) and TNM stage (p value = 0.911). A statistically significant difference was noted in the EGFR and β-catenin immunoexpression (p = 0.0001). EGFR and β-catenin expression was observed in 50% and 65% of cases, respectively. EGFR and β-catenin expression was not associated with histological tumor grade and TNM stage of the tumor. In the present study, EGFR expression was significantly associated with β-catenin immunoexpression.

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Authors and Affiliations

  1. Dept. of Pathology, ESIC Medical College & Hospital, Faridabad, Haryana, India

    Alka Yadav, Mukta Pujani, Ruchira Wadhwa, Monica Sarohi & Aiswarya AB

  2. Dept. of Pathology, NDMC Medical College and Hindu Rao Hospital, Delhi, India

    Sompal Singh & Namrata Sarin

Authors
  1. Alka Yadav
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  2. Sompal Singh
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  3. Namrata Sarin
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  4. Mukta Pujani
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  6. Monica Sarohi
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  7. Aiswarya AB
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Contributions

Alka Yadav – conception and design, data acquisition, analysis

Sompal Singh – conception and design, analysis and interpretation of the data

Namrata Sarin – conception and design, analysis and interpretation of the data

Mukta Pujani – drafting of the paper, data analysis

Ruchira Wadhwa – critical revision of the manuscript, data acquisition

Monica Sarohi – critical revision of the manuscript

Aiswarya AB – drafting of the paper, data analysis

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Correspondence to Mukta Pujani.

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Yadav, A., Singh, S., Sarin, N. et al. Expression of Epidermal Growth Factor Receptor (EGFR) and β-catenin in Colorectal Carcinoma and its Correlation with Tumor Grade and Stage. Indian J Surg Oncol 14, 758–764 (2023). https://doi.org/10.1007/s13193-023-01825-6

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