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Retroperitoneal Liposarcoma: Rational Extent of Surgery Tailored to Grade of Malignancy

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Abstract

This study was aimed at determining the indications for combined and organ-preserving operations. The study included 190 patients with retroperitoneal liposarcoma (RLPS). The influence of the following factors on the overall survival (OS) and recurrence-free survival (RFS) were studied: involvement of adjacent organs in the tumor, volume of surgical intervention. OS and RFS were worse in pathologically confirmed visceral invasion in the both RLPS low grade and high grade (p = 0.000). In RLPS low grade, there was no significant difference in OS and RFS between the group of patients who underwent combined surgery without confirmed visceral invasion and the group of patients who underwent organ–preserving surgery (p > 0.080). In RLPS high grade, OS and RFS were higher in the group of patients who underwent combined surgery without confirmed visceral invasion than in the group of patients who underwent organ–preserving surgery (p < 0.050). In RLPS low grade, it is advisable to perform organ-preserving operations, including nephrosaving operations. In RLPS high grade, the organ-preserving operations worsen long-term results and prognosis. Combined operations including nephrectomy are justified in RLPS high grade.

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Data Availability

All data generated or analysed during this study are included in this published article. Additional information about the datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Oncology, ”Center of Innovative Technologies” LLC, Euroonco Clinic, 22, Dukhovskoy Lane, Moscow, 115191, Russian Federation

    Alexander Yu. Volkov

  2. Department of Abdominal Surgery, FSBI «National Medical Research Center of Oncology Named After N.N. Blokhin» of the Ministry of Health of Russia, Moscow, Russian Federation

    Sergey N. Nered, Ivan S. Stilidi & Peter P. Arhiri

  3. Department of Pathology, FSBI «National Medical Research Center of Oncology Named After N.N. Blokhin» of the Ministry of Health of Russia, Moscow, Russian Federation

    Nikolay A. Kozlov

  4. Department of Chemotherapy, FSBI «National Medical Research Center of Oncology Named After N.N. Blokhin» of the Ministry of Health of Russia, Moscow, Russian Federation

    Elena Yu. Antonova

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  1. Alexander Yu. Volkov
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Volkov, A.Y., Nered, S.N., Kozlov, N.A. et al. Retroperitoneal Liposarcoma: Rational Extent of Surgery Tailored to Grade of Malignancy. Indian J Surg Oncol 15 (Suppl 1), 38–44 (2024). https://doi.org/10.1007/s13193-023-01726-8

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