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Treatment of Peritoneal Surface Malignancies with Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy (HIPEC): Experience in Israel

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Abstract

The treatment of peritoneal surface malignancies, either primary or secondary (peritoneal metastasis), has evolved over the past two decades. A nihilistic approach of incurable “carcinomatosis” is changing into treatment of peritoneal metastasis with curative intent. The aim of the present study is to review the current practice, past history, and future of peritoneal surface oncology in Israel. A systematic review of all patients treated in institutions performing cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy (HIPEC) for the treatment of peritoneal surface malignancies. Each center provided the following data: start year, number of total cases, number of cases performed in 2017, and the method used (open vs. closed technique). Between 1990 and 2018, there were 1462 patients treated by CRS/HIPEC in Israel by eight different surgical groups in six medical centers. Currently, there are seven surgical groups in six medical centers routinely performing CRS/HIPEC. The annual rate of CRS/HIPEC was 171 cases in 2017 with a range of (4–69 cases/center). This is the first step of establishing an Israeli Peritoneal Surface Oncology Group that will have joined database and perform clinical trials in this challenging field of surgical oncology.

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Author information

Author notes

  1. Joseph Klausner and Aviram Nissan contributed equally to this work.

Authors and Affiliations

  1. Department of General and Oncological Surgery-Surgery C, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel

    Almog Ben-Yaacov, Dov Zippel, Gur Ben-Ari & Aviram Nissan

  2. Department of Surgery, Tel Aviv-Sourasky Medical Center Israel, Tel Aviv, Israel

    Eran Nizri, Guy Lahat, Shlomo Schneibaum & Joseph Klausner

  3. Department of Surgery-B, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel

    Yaniv Berger & Mordechai Gutman

  4. Department of Surgery, Rabin Medical Center, Beilinson Campus, Petah-Tikvah, Israel

    Eran Sadot & Daniel Benchimol

  5. Department of Surgery, Assaf Harofe Medical Center, Tzrifin, Israel

    Ron Lavi & Ariel Halevy

  6. Department of Surgery, Soroka Medical Center, Beer Sheva, Israel

    Gilbert Sebbag & Itzhak Avital

  7. Department of Surgery, Rambam Medical center, Haifa, Israel

    Aviad Hoffman

Authors
  1. Almog Ben-Yaacov
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  2. Eran Nizri
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  3. Guy Lahat
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  4. Yaniv Berger
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  5. Eran Sadot
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  6. Ron Lavi
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  7. Dov Zippel
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  8. Gilbert Sebbag
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  9. Itzhak Avital
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  10. Aviad Hoffman
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  11. Mordechai Gutman
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  12. Ariel Halevy
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  13. Shlomo Schneibaum
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  14. Gur Ben-Ari
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  15. Daniel Benchimol
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  16. Joseph Klausner
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  17. Aviram Nissan
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Consortia

For the Israeli Peritoneal Oncology Research Group

Corresponding author

Correspondence to Aviram Nissan.

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Ben-Yaacov, A., Nizri, E., Lahat, G. et al. Treatment of Peritoneal Surface Malignancies with Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy (HIPEC): Experience in Israel. Indian J Surg Oncol 10 (Suppl 1), 19–23 (2019). https://doi.org/10.1007/s13193-019-00874-0

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  • DOI: https://doi.org/10.1007/s13193-019-00874-0

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