Abstract
Lymphoepithelioma –like carcinomas (LELCs) are tumors with histological features similar to those of lymphoepithelioma of nasopharynx. They have been described in many organs including female genital tract. Their histology is characterized by sheets, nests and cords of large syncytial tumor cells containing round nuclei with prominent nucleoli and dense lymphoplasmacytic infiltrate in the stoma. The association of Epstein-Barr virus (EBV) with LELCs has not been observed in western patients. But a few Asian patients with these tumors in uterine cervix have shown positive association of EBV. Cervical LELCs harbor EBV more frequently than cervical squamous cell carcinomas. These tumors are rarer in endometrium. Only 3 cases have been reported and the association of EBV has not been observed. We present here a rare case of LELC in endometrial polyp from India, who presented with postmenopausal vaginal bleeding. The tumor cells were positive for cytokeratin and EBV Latent membrane protein-1.
Similar content being viewed by others
References
Shousha S, Luqmini YA (1994) Epstein-Barr virus in gastric carcinoma and adjacent normal gastric and duodenal mucosa. J Clin Pathol 47:695–8
Leung SY, Chung LP, Yuen ST, Ho CM, Wong MP, Chan SY (1995) Lymphoepithelial carcinoma of the salivary gland: in situ detection of Epstein-Barr virus. J Clin Pathol 48:1022–27
Butler AE, Colby TV, Weiss L, Lombard C (1989) Lymphoepithelioma-like carcinoma of the lung. Am J Surg Pathol 13:632–9
Wick MR, Scheithauer BW, Weiland LH, Bernatz PE (1982) Primary thymic carcinomas. Am J Surg Pathol 6:613–30
Amin MB, Ro JY, Lee KM et al (1994) Lymphoepithelioma-like carcinoma of the urinary bladder. Am J Surg Pathol 18:466–3
Dadmanesh F, Peterse JL, Sapino A, Fonelli A, Eusebi V (2001) Lymphoepithelioma-like carcinoma of the breast: lack of evidence of Epstein-Barr virus infection. Histopathology 38:54–61
Tseng C-J, Pao C-C, Seng L-H, Chang C-T, Lai C-H, Soong Y-K et al (1997) Lymphoepithelioma-like carcinoma of the uterine cervix. Association with epstein-barr virus and human papilloma virus. Cancer 80:91–7
Axelsen SM, Stamp IM (1995) Lymphoepithelioma-like carcinoma of the vulvar region. Histopathology 27:281–3
Dietl J, Horny HP, Kaiserling E (1994) Lymphoepithelioma-like carcinoma of the vagina: a case report with special reference the immunophenotype of the tumor cells and tumor infiltrating lymph reticular cells. Int J Gynecol Pathol 13:186–9
Lee S, Yoon S, Hong EK, Ro JY (2007) Lymphoepithelioma-like carcinoma of the ovary: a case report and review of the literature. Arch Pathol Lab Med 131:1715–8
Perla Vargas M, Merino MJ (1998) Lymphoepithelioma-like carcinoma: an unusual variant of endometrial cancer: a report of two cases. Int J Gynecol Pathol 17:272–6
Rahimi S, Lena A, Vittori G (2007) Endometrial lymphoepithelioma like carcinoma: absence of Epstein-Barr virus genomes. Int J Gynecol Cancer 17:532–5
Barnes L, Eveson JW, Reichart P, Sidransky D (eds) (2005) World health organization classification of tumors. Pathology and genetics of head and neck tumors. IARC Press, Lyon, p 85–97
Castro CY, Ostrowki ML, Borrios R (2001) Relationship between Epstein-Barr virus and lymphoepithelioma-like carcinoma of the lung: a clinicopathologic study of 6 cases and review of the literature. Hum Pathol 32:863–72
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Makannavar, J.H., KishanPrasad, H. & Shetty, J.K. Lymphoepithelioma-like Carcinoma of Endometrium; A Rare Case Report. Indian J Surg Oncol 6, 130–134 (2015). https://doi.org/10.1007/s13193-015-0405-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13193-015-0405-0