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Parotid carcinoma: Current diagnostic workup and treatment

  • Review Article
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Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

In this review we present recent progress in diagnostic workup, prognostic evaluation, treatment options and resulting outcomes. Whenever possible, complete resection remains the mainstay of treatment. Sacrifice of facial nerve branches is reserved for the clinically or electromyographically dysfunctioning facial nerve. Clinical or radiological neck disease demands combined surgery and radiotherapy. Treatment of the N0 neck is indicated for advanced stage-high grade tumors but the question remains unanswered whether this should be surgical or radiotherapeutic elective treatment. Surgery alone will cure low stage, low grade tumors, that show no additional negative prognostic factors following adequate resection. In all other tumors postoperative radiotherapy will improve locoregional control. This approach results in good locoregional control, in a way that distant metastasis remains the typical presentation of treatment failure. In this setting, the results of systemic treatment today remain limited, but a huge effort in the molecular biology field has been done to introduce targeted therapy into this domain of head and neck cancer. Disease control remains variable within the patient population. This variation can increasingly be predicted by systems that incorporate the combined information of multivariately identified and quantified prognostic factors into an individualized prognosis for the parotid carcinoma patient.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Head and Neck Surgery and Leuven Cancer Institute, University Hospitals Leuven, KULeuven, Leuven, Belgium

    Vincent L. M. Vander Poorten

  2. European Salivary Gland Society, Geneva, Switzerland

    Vincent L. M. Vander Poorten

  3. Department of Otorhinolaryngology, Head and Neck Surgery, CHU Geneve and Hôpital Général Beaulieu, European Salivary Gland Society, Geneva, Switzerland

    Francis Marchal

  4. Department of Radiotherapy-Oncology and Leuven Cancer Institute, University Hospitals Leuven, KULeuven, Leuven, Belgium

    Sandra Nuyts

  5. Department of Medical Oncology and Leuven Cancer Institute, University Hospitals Leuven, KULeuven, Leuven, Belgium

    Paul M. J. Clement

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Vander Poorten, V.L.M., Marchal, F., Nuyts, S. et al. Parotid carcinoma: Current diagnostic workup and treatment. Indian J Surg Oncol 1, 96–111 (2010). https://doi.org/10.1007/s13193-010-0022-x

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  • DOI: https://doi.org/10.1007/s13193-010-0022-x

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