Abstract
Aim-Background
To evaluate the local recurrence rate after potentially curative low anterior resection and to determine factors influencing local recurrence.
Methods
Two hundred and sixty-nine patients were included in this retrospective clinical study. Studied variables were sex, age, location, size, grade and stage of tumour, surgical and histological clearance margins, height of vessel ligation, total mesorectal excision, number of resected and infiltrated lymph nodes and inflammatory response.
Results
Local recurrence rate was 10%. According to univariate analysis, tumours classified as advanced Astler-Coller stage or over 3 cm in size, mild inflammatory reaction, and more than three infiltrated lymph nodes increased the recurrence rate. Multivariate analysis demonstrated that age under 60, enlarged tumour size, high grade, short clearance margin, presence of infiltrated lymph nodes and mild inflammatory reaction were independent negative prognostic factors.
Conclusions
Low anterior resection is a safe and effective procedure in the hands of general surgeons without expertise in rectal surgery.
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References
Porter GA, Soskolne CL, Yakimets WW, Newman SC. Surgeon-related factors and outcome in rectal cancer. Ann Surg 1998; 227:157–167
Marsh P, James R, Schofield P. Definition of local recurrence after surgery for rectal carcinoma. Br J Surg 1995; 82:465–468
Dent O, Chapuis P, Bokey E. Methodology and reporting in studies of local recurrence after curative excision of the rectum for cancer. Br J Surg 2001; 88:1476–1480
Killingback M, Barron P, Dent O. Local recurrence after curative resection of cancer of the rectum without total mesorectal excision. Dis Colon Rectum 2001; 44:473–483
Manfredi S, Benhamiche AM, Meny B, Cheynel N, Rat P, Faivre J. Population-based study of factors influencing occurrence and prognosis of local recurrence after surgery for rectal cancer. Br J Surg 2001; 88:1221–1227
Beck DE, Reickert CA, Margolin DA, Whitlow CB, Timmcke AE, Hicks TC. Local recurrence, distant recurrence and survival of rectal cancer. Ochsner J 2006; 6:59–63
Kusters M, Marijnen CA, van de Velde CJ, Rutten HJ, Lahaye MJ, Kim JH, et al. Patterns of local recurrence in rectal cancer; a study of the Dutch TME trial. Eur J Surg Oncol 2010; 36:470–476
Law WL, Chu KW. Anterior resection for rectal cancer with mesorectal excision: a prospective evaluation of 622 patients. Ann Surg 2004; 240:260–268
Portier G, Ghouti L, Kirzin S, Guimbaud R, Rives M, Lazorthes F. Oncological outcome of ultra-low coloanal anastomosis with and without intersphincteric resection for low rectal adenocarcinoma. Br J Surg 2007; 94:341–345
Mathis KL, Larson DW, Dozois EJ, Cima RR, Huebner M, Haddock MG, et al. Outcomes following surgery without radiotherapy for rectal cancer. Br J Surg 2012; 99:137–143
Heald RJ, Moran BJ, Ryall RD, Sexton R, MacFarlane JK. Rectal cancer. The Basingstoke experience of total mesorectal excision 1978–1997. Arch Surg 1998; 133:894–899
Arbman G, Nilsson E, HAlbook O, Sjodahl R. Local recurrence following total mesorectal excision for rectal cancer. Br J Surg 1996; 83:375–379
Dixon AR, Maxwell WA, Thornton Holmes J. Carcinoma of the rectum: a 10-year experience. Br J Surg 1991; 78:308–311
Polglase A, McMurrick P, Tremayne A, Bhathal P. Local recurrence after curative anterior resection with principally blunt dissection for carcinoma of the rectum and rectosigmoid. Dis Colon Rectum 2001; 44:947–953
Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery-the clue to pelvic recurrence? Br J Surg 1982; 69:613–616
Heald RJ, Ryall RD. Recurrence and survival after total mesorectal excision for rectal cancer. Lancet 1986; 2:1479–1482
Simons AJ, Ker R, Groshen S, Gee C, Anthone GJ, Ortega AE, et al. Variations in treatment of rectal cancer: the influence of hospital type and caseload. Dis Colon Rectum 1997; 40:641–646
Wasmuth HH, Nestvold T, Røkke O. Low Local recurrence rates after rectal cancer resection with limited use of preoperative radiotherapy. Scand J Surg 2008; 97:231–236
Nesbakken A, Nygaard K, Westerheim O, Mala T, Lunde OC. Local recurrence after mesorectal excision for rectal cancer. EJSO 2002; 28:126–134
Skandalakis JE. Skandalakis’ Surgical Anatomy. Paschalidis Medical Publications 2007
Colombo PL, Foglieni CL, Morone C. Analysis of recurrence following curative low anterior resection and stapled anastomoses for carcinoma of the middle third and lower rectum. Dis Colon Rectum 1987; 30:457–464
National Cancer Institute: PDQ. Rectal Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified 〈03/25/2011〉
Balch GC, De Meo A, Guillem JG. Modern management of rectal cancer: a 2006 update. World J Gastroenterol 2006; 12:3186–3195
Baxter NN, Garcia-Aguilar J. Organ preservation for rectal cancer. J Clin Oncol 2007; 25:1014–1020
Petronella P, Scorzelli M, Manganiello A, Nunziata L, Ferretti M, Campitiello F, et al. Our experience of total mesorectal excision for rectal cancers. Hepatogastroenterology 2010; 57:482–486
DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 8th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2008; p. 1663–1682
Compton CC, Greene FL. The staging of colorectal cancer: 2004 and beyond. CA Cancer J Clin 2004; 54:295–308
Swanson RS, Compton CC, Stewart AK, Bland KI. The prognosis of T3N0 colon cancer is dependent on the number of lymph nodes examined. Ann Surg Oncol 2003; 10:65–71
Le Voyer TE, Sigurdson ER, Hanlon AL, Mayer RJ, Macdonald JS, Catalano PJ, et al. Colon cancer survival is associated with increasing number of lymph nodes analyzed: a secondary survey of intergroup trial INT-0089. J Clin Oncol 2003; 21:2912–2919
Prandi M, Lionetto R, Bini A, Francioni G, Accarpio G, Anfossi A, et al. Prognostic evaluation of stage B colon cancer patients is improved by an adequate lymphadenectomy: results of a secondary analysis of a large scale adjuvant trial. Ann Surg 2002; 235:458–463
Tepper JE, O’Connell MJ, Niedzwiecki D, Hollis D, Compton C, Benson AB 3rd, et al. Impact of number of nodes retrieved on outcome in patients with rectal cancer. J Clin Oncol 2001; 19:157–163
Halvorsen TB, Seim E. Association between invasiveness, inflammatory reaction, desmoplasia and survival in colorectal cancer. J Clin Pathol 1989; 42:162–166.
Klintrup K, Mäkinen JM, Kauppila S, Väre PO, Melkko J, Tuominen H, et al. Inflammation and prognosis in colorectal cancer. Eur J Cancer 2005; 41:2645–2654
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Karydakis, P., Kyriakidis, A.V., Svoronos, G. et al. Is low anterior resection for rectal cancer equally efficient in the hands of non-expertised surgeons?. Hellenic J Surg 86, 10–18 (2014). https://doi.org/10.1007/s13126-014-0087-z
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DOI: https://doi.org/10.1007/s13126-014-0087-z