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The role of lamin A/C in mesenchymal stem cell differentiation

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Abstract

Lamin A/C is the major architectural protein of cell nucleus in charge of the nuclear mechanosensing. By integrating extracellular mechanical and biochemical signals, lamin A/C regulates multiple intracellular events including mesenchymal stem cell (MSC) fate determination. Herein, we review the recent findings about the effects and mechanisms of lamin A/C in governing MSC lineage commitment, with a special focus on osteogenesis and adipogenesis. Better understanding of MSC differentiation regulated by lamin A/C could provide insights into pathogenesis of age-related osteoporosis.

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Abbreviations

ECM:

Extracellular matrix

HGPS:

Hutchinson-Gilford progeria syndrome

KASH:

Klarsicht/ANC-1/Syne homology

LINC:

Linkers of nucleoskeleton and cytoskeleton

MKL1:

Megakaryoblastic leukemia 1

MSC:

Mesenchymal stem cell

RA:

Retinoic acid

RAR:

Retinoic acid receptors

RARE:

RA-responsive elements

SRF:

Serum response factor

SUN:

Sad1/UNC-84

YAP:

Yes-associated protein

TAZ:

transcriptional co-activators with PDZ-binding motif

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Funding

This work was supported by grants from the National Natural Science Foundation of China (31470904, Zhihe Zhao; 81400522, Rui Ye).

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  1. Bo Zhang and Yang Yang contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China

    Bo Zhang, Yang Yang, Reziwan Keyimu, Zhihe Zhao & Rui Ye

  2. Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China

    Bo Zhang, Reziwan Keyimu, Zhihe Zhao & Rui Ye

  3. Department of General Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China

    Yang Yang

  4. Program in Biological Sciences in Dental Medicine, Harvard School of Dental Medicine, Boston, MA, USA

    Jin Hao

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  1. Bo Zhang
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Zhang, B., Yang, Y., Keyimu, R. et al. The role of lamin A/C in mesenchymal stem cell differentiation. J Physiol Biochem 75, 11–18 (2019). https://doi.org/10.1007/s13105-019-00661-z

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