Abstract
The primary features of Alzheimer’s disease (AD) are extracellular amyloid plaques consisting mainly of deposits of amyloid β (Aβ) peptides and intracellular neurofibrillary tangles (NFTs). Sets of evidence suggest that interleukin-5 (IL-5) is involved in the pathogenesis of AD. Herein, we investigated the protective role of IL-5 in PC12 cells, to provide new insights into understanding this disease. Western blot was employed to assess the protein levels of Bax and phospho-tau as well as phospho-JAK2; MTT assay was performed to decipher cell viability. Treatment of IL-5 decreased Aβ25–35-induced tau phosphorylation and apoptosis, effects blunted by JAK2 inhibition. IL-5 prevents Aβ25–35-evoked tau protein hyperphosphorylation and apoptosis through JAK2 signaling.
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Yuanyuan Zhou and Chaoyan Li contributed equally and thus share the first authorship
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Zhou, Y., Li, C., Li, D. et al. IL-5 blocks apoptosis and tau hyperphosphorylation induced by Aβ25–35 peptide in PC12 cells. J Physiol Biochem 73, 259–266 (2017). https://doi.org/10.1007/s13105-017-0550-8
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DOI: https://doi.org/10.1007/s13105-017-0550-8