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Optical Coherence Tomography in Cerebrovascular Disease: Open up New Horizons

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Abstract

Optical coherence tomography (OCT), based on the backscattering or reflection of near-infrared light, enables an ultra-high resolution of up to 10 μm. The successful application of OCT in coronary artery diseases has sparked increasing interest in its implementation in cerebrovascular diseases. OCT has shown promising potential in the atherosclerotic plaque structure characterization, plaque rupture risk stratification, pre-stenting and post-stenting evaluation, and long-term follow-up in extracranial and intracranial atherosclerotic stenosis (ICAS). In hemorrhagic cerebrovascular diseases, OCT plays an important role in the structure evaluation, rupture risk stratification, and healing and occlusion evaluation following initial treatment in intracranial aneurysms (IAs). In this study, we summarized the applications of OCT in the diagnosis, treatment, and follow-up of cerebrovascular diseases, especially in ICAS and IAs. The current limitations and future directions of OCT in the endovascular treatment of cerebrovascular diseases were also discussed.

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Funding

This work was supported by the Beijing Scientific and Technologic Project (Z201100005520019) and Xuanwu Hospital Science Program for Fostering Young Scholars (QNPY2020010).

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  1. Ran Xu and Qing Zhao contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China

    Ran Xu, Tao Wang, Jichang Luo, Xiao Zhang, Yao Feng, Yan Ma, Bin Yang & Liqun Jiao

  2. China International Neuroscience Institute (China-INI), 45 Changchun Street, Beijing, 100053, China

    Ran Xu, Tao Wang, Jichang Luo, Xiao Zhang, Yao Feng, Yan Ma, Bin Yang & Liqun Jiao

  3. M.D. Program, Peking Union Medical College, No. 9 Dongdansantiao Street, Beijing, 100730, China

    Qing Zhao

  4. Faculty of Medicine, National Heart & Lung Institute, Imperial College London, G210 Guy Scadding Building, London, SW3 6LY, UK

    Yutong Yang

  5. Neuroendovascular Program, Massachusetts General Hospital, Boston, MA, 02114, USA

    Adam A. Dmytriw

  6. Neuroradiology & Neurointervention Service, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 02215, USA

    Adam A. Dmytriw

  7. National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Science, Beijing, 100190, China

    Ge Yang

  8. Department of Neurosurgery, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan 2nd Road, Guangzhou, 510080, Guangdong Province, China

    Shengpan Chen

  9. Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing, 100053, China

    Liqun Jiao

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  1. Ran Xu
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Xu, R., Zhao, Q., Wang, T. et al. Optical Coherence Tomography in Cerebrovascular Disease: Open up New Horizons. Transl. Stroke Res. 14, 137–145 (2023). https://doi.org/10.1007/s12975-022-01023-6

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