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Impact of Electronic Cigarette Vaping on Cerebral Ischemia: What We Know So Far

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Abstract

Electronic cigarettes (ECs) are battery-powered nicotine delivery devices that have rapidly gained popularity and attention globally. ECs work by heating a liquid to produce an aerosol that usually contains nicotine, flavoring compounds, and other chemicals, which are inhaled during vaping. EC aerosols are depicted to contain a lower number and overall quantity of harmful toxicants than conventional cigarettes (CCs). However, emerging research indicates that EC aerosols contain harmful ingredients including ultrafine particles, volatile organic compounds, and heavy metals. One common ingredient found in both CCs and ECs is nicotine, which has been shown to be both highly addictive and toxic. Particularly relevant to our current review, there is an enormous amount of literature that shows that smoking-derived nicotine exacerbates ischemic brain damage. Therefore, the question arises: will EC use impact the outcome of stroke? ECs are highly popular and relatively new in the market; thus, our understanding about the long-term effects of EC use on brain are lacking. The current review strives to extrapolate the existing understanding of the nicotine-induced effects of conventional smoking on the brain to the possible effects that ECs may have on the brain, which may ultimately have a potential for adverse stroke risk or severity.

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Funding

This work was supported by an endowment from Drs. Chantal and Peritz Scheinberg and Florida Department of Health # 20K09 (Ami P. Raval).

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  1. Jonathan Siegel and Shahil H. Patel contributed equally to this work.

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  1. Peritz Scheinberg Cerebral Vascular Disease Research Laboratory, Department of Neurology, Leonard M. Miller School of Medicine, University of Miami, Neurology Research Building, 1420 NW 9th AvenueRoom # 203H, Miami, FL, 33136, USA

    Jonathan Siegel, Shahil H. Patel, Berk Mankaliye & Ami P. Raval

  2. Bruce W. Carter Department of Veterans Affairs Medical Center, Miami, FL, 33136, USA

    Ami P. Raval

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AR conceived the scientific idea and discussed outline of the review. SP, JS, and BM wrote a draft, and AR provided critical review and revision of the manuscript.

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Correspondence to Ami P. Raval.

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All institutional and national guidelines for the care and use of laboratory animals were followed. Animal usage and experimentation were approved by the Institutional Animal Care and Use Committee at the University of Miami and were in accordance with the US Public Health Service’s Policy on Humane Care and Use of Laboratory Animals.

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Ami P. Raval is one of the associate editors of the TSRJ. The other authors declare no competing interests.

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Siegel, J., Patel, S.H., Mankaliye, B. et al. Impact of Electronic Cigarette Vaping on Cerebral Ischemia: What We Know So Far. Transl. Stroke Res. 13, 923–938 (2022). https://doi.org/10.1007/s12975-022-01011-w

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