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Antihepatotoxic Activity of Liposomal Silibinin

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Abstract

The liposomal form of silibinin was obtained, and its antihepatotoxic activity in mice was studied using a model of acute toxic hepatitis caused by injection of carbon tetrachloride or paracetamol. It was shown that the use of the drug in therapy or prevention regimens leads to normalization of levels of transaminases and total protein in the blood of experimental animals. The results of the study showed that liposomal silibinin when administered intravenously shows a more pronounced hepatoprotective effect compared to intragastric administration of free silibinin. Thus, the effectiveness of the therapeutic action of silibinin can be significantly increased by using its liposomal form. Liposomal drug, in contrast to native silibinin, can be injected directly into the blood that significantly increases its bioavailability.

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Acknowledgements

The work is performed according to the Russian Government Program of Competitive Growth of I.M. Sechenov First Moscow State University.

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Authors and Affiliations

  1. Biotechnology Department, I.M. Sechenov First Moscow State Medical University, 119991 8-2 Trubetskaya Str, Moscow, Russian Federation

    Sergey V. Lutsenko, Tatiana I. Gromovykh & Nataliya B. Feldman

  2. Analytical, Physical and Colloid Chemistry Department, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

    Ivan I. Krasnyuk Jr

  3. Technopark Department, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

    Ivan A. Vasilenko

  4. All-Russian Research Institute of Medicinal and Aromatic Plants, Moscow, Russian Federation

    Nataliya B. Feldman

Authors
  1. Sergey V. Lutsenko
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  2. Tatiana I. Gromovykh
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  3. Ivan I. Krasnyuk Jr
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  4. Ivan A. Vasilenko
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Correspondence to Nataliya B. Feldman.

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All animal experiments were approved by the All-Russian Research Institute of Medicinal and Aromatic Plants Bioethics Committee.

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The authors declare no conflict of interest.

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Lutsenko, S.V., Gromovykh, T.I., Krasnyuk, I.I. et al. Antihepatotoxic Activity of Liposomal Silibinin. BioNanoSci. 8, 581–586 (2018). https://doi.org/10.1007/s12668-018-0512-9

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  • DOI: https://doi.org/10.1007/s12668-018-0512-9

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