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Serotonin Modulation of Premotor Interneuron Excitability in the Snail during Associative Learning

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Abstract

It is shown that after the elaboration of a conditioned reflex in snails, a reliable decrease can be observed in the membrane potential (Vm) of the premotor interneurons at 4 mV, daily injection of serotonin (5-HT) causes a decrease in Vm at 4.5 mV, the same change is observed for Vm in the snails trained after the injection of 5-HT. A single injection of 5-HT causes a depolarization shift of Vm at 5 mV. After the initial stage of training (10–12 pairs) the snails, injected by 5-HT, there is a depolarization at 4.5 mV.

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Acknowledgments

This work was funded by the subsidy of the Russian Government to support the Program of Competitive Growth of Kazan Federal University among the World’s Leading Academic Centers (agreement No.02.A03.21.0002) and by Russian Fund of Basic Research (grant No. 15-04-05487_a).

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Authors and Affiliations

  1. Laboratory of Neurobiology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia

    Aleksandra N. Golovchenko, Tatiana Kh. Bogodvid, Lyudmila N. Muranova & Khalil L. Gainutdinov

  2. Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia

    Vyatcheslav V. Andrianov

  3. Zavoisky Physical-Technical Institute of Russian Academy of Sciences, Kazan, Russia

    Vyatcheslav V. Andrianov & Khalil L. Gainutdinov

  4. Volga Region State Academy of Physical Culture, Sport and Tourism, Kazan, Russia

    Tatiana Kh. Bogodvid

Authors
  1. Aleksandra N. Golovchenko
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  2. Vyatcheslav V. Andrianov
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  3. Tatiana Kh. Bogodvid
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  4. Lyudmila N. Muranova
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  5. Khalil L. Gainutdinov
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Correspondence to Khalil L. Gainutdinov.

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Golovchenko, A.N., Andrianov, V.V., Bogodvid, T.K. et al. Serotonin Modulation of Premotor Interneuron Excitability in the Snail during Associative Learning. BioNanoSci. 6, 450–452 (2016). https://doi.org/10.1007/s12668-016-0252-7

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  • DOI: https://doi.org/10.1007/s12668-016-0252-7

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