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Bridging the Scales to Explore Cellular Adaptation and Remodeling

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Abstract

This short paper presents a multiscale framework to better understand the mechanisms of biological tissue evolution from molecular to tissue scale. For this, a bottom-up strategy is proposed in which mechano-sensitive molecular processes, the evolution of cell architecture and contraction as well as the interaction between cells and the extra-cellular matrix can be integrated in a single framework. Preliminary studies based on this approach suggest that mechano-sensitive feed-back mechanisms at several length-scales may be a key element to understand tissue adaptivity to tis mechanical environment.

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Acknowledgement

FJV gratefully acknowledges the University of Colorado CRCW Seed Grant in support of this research.

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Authors and Affiliations

  1. Department of Civil, Environmental and Architectural Engineering, University of Colorado, Boulder, CO, USA

    Franck J. Vernerey, Louis Foucard & Mehdi Farsad

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  1. Franck J. Vernerey
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  2. Louis Foucard
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  3. Mehdi Farsad
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Correspondence to Franck J. Vernerey.

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Vernerey, F.J., Foucard, L. & Farsad, M. Bridging the Scales to Explore Cellular Adaptation and Remodeling. BioNanoSci. 1, 110–115 (2011). https://doi.org/10.1007/s12668-011-0013-6

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  • DOI: https://doi.org/10.1007/s12668-011-0013-6

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