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Osseous Plasma Cell Neoplasm of the Mandible for Initial Diagnosis of Multiple Myeloma: Case Report and Literature Review

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Journal of Maxillofacial and Oral Surgery Aims and scope Submit manuscript

Abstract

Purpose

Plasmocytoma of the bone represents a variance of plasma cell neoplasms, which often gives hint for systemic affection. A case of a mandibular tumor as first manifestation of multiple myeloma (MM) is presented and discussed with the literature.

Materials and Methods

A 76-year old female with pain and swelling of the right lower jaw was assigned to the hospital. Radiograph showed a lytic tumor at the mandibular condyle and histological analysis gave evidence of a plasma cell tumor with positivity to CD138. In further examinations, elevated immunoglobulin levels in serum and osseous plasma cell infiltration unveiled MM. PubMed-database was searched by “multiple myeloma primary lesion jaw”, “multiple myeloma primary manifestation mandible” and “multiple myeloma mandibular lesion” within the last 30 years.

Results

Together with the current case, 11 reports including 13 patients were found describing mandibular plasmocytoma as first sign for MM. Mean age was 59 years with slight female preference. Initial symptoms were mostly swelling episodes with or without pain. The main radiological presentation was a uni- or multilocular radiolucency. After a mean follow up time of 29 months (stated in 8 cases; standard deviation 50, min: 1, max: 151), 3/8 patients died and in 5/8 cases, signs of progress were seen.

Conclusion

In rare cases, occurrence of plasmocytoma of the mandible is first sign for MM and should always lead to further investigations regarding systemic disease. Simple examinations such as panoramic X-rays can lead to early detection of MM and thereby better prognosis by earlier treatment.

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Conflict of interest

The authors state that there is no conflict of interest.

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Authors and Affiliations

  1. Department of Oral, Maxillofacial and Plastic Surgery, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany

    E. Goetze & C. Walter

  2. M.R. Ambedkar Dental College and Hospital, Bangalore, India

    P. W. Kämmerer

  3. Department of Oral, Maxillofacial and Plastic Surgery, University Medical Center Rostock, Schillingallee 35, 18055, Rostock, Germany

    P. W. Kämmerer

Authors
  1. E. Goetze
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  2. C. Walter
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  3. P. W. Kämmerer
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Correspondence to P. W. Kämmerer.

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Goetze, E., Walter, C. & Kämmerer, P.W. Osseous Plasma Cell Neoplasm of the Mandible for Initial Diagnosis of Multiple Myeloma: Case Report and Literature Review. J. Maxillofac. Oral Surg. 14 (Suppl 1), 469–474 (2015). https://doi.org/10.1007/s12663-014-0688-7

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  • DOI: https://doi.org/10.1007/s12663-014-0688-7

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