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Polymorphous Low Grade Adenocarcinoma: Literature Review and Report of Lower Lip Lesion with Suspected Lung Metastasis

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Abstract

Polymorphous low grade adenocarcinoma (PLGA) is an uncommon tumour that affects minor salivary glands mainly. It was known to be clinically benign and histologically polymorphic; sometimes misdiagnosed as pleomorphic adenomas, monomorphic adenomas, malignant pleomorphic adenomas, adenoid cystic carcinomas and adenocarcinoma not otherwise specified. More information about PLGA is cumulating in the current literature with new evidences suggesting that the tumour may not be as indolent as it was previously thought. A thorough understanding of the clinical and histological behaviour of the lesion has serious implications in management. Here, a case of lower lip lesion with suspected lung metastasis is reported to exemplify how the clinical behaviour of the lesion may affect management.

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References

  1. Freedman PD, Lumerman H (1983) Lobular carcinoma of intraoral minor salivary gland origin. Report of twelve cases. Oral Surg 56:157–165

    Article  PubMed  CAS  Google Scholar 

  2. Vincent SD, Hammond HL, Finkelstein MW (1994) Clinical and therapeutic features of polymorphous low-grade adenocarcinoma. Oral Surg Oral Med Oral Pathol 77:41–47

    Article  PubMed  CAS  Google Scholar 

  3. Evans HL, Batsakis JG (1984) Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of distinctive neoplasm. Cancer 53:935–942

    Article  PubMed  CAS  Google Scholar 

  4. Hannen EJ, Bulten J, Festen J et al (2000) Polymorphous low-grade adenocarcinoma with distant metastases and deletions on chromosome 6q23-qter and 11q23-qter: a case report. J Clin Pathol 53:942–945

    Article  PubMed  CAS  Google Scholar 

  5. Lee VK, McCaughan BC, Scolyer RA (2004) Polymorphous low-grade adenocarcinoma in the lung: a case report. Int J Surg Pathol 12:287–292

    Article  PubMed  Google Scholar 

  6. Lengyel E, Somogyi A, Godney M et al (2000) Polymorphous low-grade adenocarcinoma of the nasopharynx. Case report and review of literature. Strahlenther Onkol 176:40–42

    Article  PubMed  CAS  Google Scholar 

  7. Tanaka F, Wada H, Inui K et al (1995) Pulmonary metastasis of polymorphous low-grade adenocarcinoma of the minor salivary gland. Thorac Cardiovasc Surg 43:178–180

    Article  PubMed  CAS  Google Scholar 

  8. Toida M, Shimokawa K, Makita H et al (2005) Intra oral minor salivary gland tumours: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg 34:528–532

    Article  PubMed  CAS  Google Scholar 

  9. Waldron CA, el-Mofty SK, Gnepp DR (1988) Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol. 66:323–333

    Article  PubMed  CAS  Google Scholar 

  10. Yih WY, Kratochvil FJ, Stewart JC (2005) Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofacial Surg 63:805–810

    Article  Google Scholar 

  11. Asioli S, Marucci G, Ficarra G et al (2006) Polymorphous adenocarcinoma of the breast. Report of three cases. Virchows Arch 448:29–34

    Article  PubMed  Google Scholar 

  12. Charous DD, Cunnane MF, Rosen MR et al (2005) Recurrent polymorphous low-grade adenocarcinoma manifesting as a sinonasal mass: a case report. Ear Nose Throat J 84:354–357

    PubMed  Google Scholar 

  13. Thomas KM, Cumberworth VL, McEwan J (1995) Orbital and skin metastasis in polymorphous low-grade adenocarcinoma of the salivary gland. J Laryngol Otol 109:1222–1225

    PubMed  CAS  Google Scholar 

  14. Young S, Leon M, Talerman A et al (2003) Polymorphous low-grade adenocarcinoma of the vulva and vagina: a tumor resembling adenoid cystic carcinoma. Int J Surg Pathol 11:43–49

    Article  PubMed  Google Scholar 

  15. Kyu Do Cho, Ji Han Jung, Deog Gon Cho et al (2007) Primary polymorphous low grade adenocarcinoma of lung treated by sleeve bronchial resection: a case report. J Korean Med Sci 22:373–376

    Article  Google Scholar 

  16. Simpson RH, Pereira EM, Ribeiro AC et al (2002) Polymorphous low grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma. Histopathology 41:250–259

    Article  PubMed  CAS  Google Scholar 

  17. Harry L, Evans MD, Mario A et al (2000) Polymorphous low-grade adenocarcinoma a study of 40 cases with long-term follow up and an evaluation of the importance of papillary areas. Am J Surg Pathol 24:1319–1328

    Article  Google Scholar 

  18. Pelkey TJ, Mills SE (1999) Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland. Am J Clin Pathol 111:785–791

    PubMed  CAS  Google Scholar 

  19. Chaâbouni S, Ayadi L, Dhouib H et al (2008) Polymorphous low-grade adenocarcinoma: a palatine and a labial location. Rev Stomatol Chir Maxillofac 109:178–182

    Article  PubMed  Google Scholar 

  20. Castle JT, Thompson LD, Frommelt RA et al (1999) Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. Cancer 86:207–219

    Article  PubMed  CAS  Google Scholar 

  21. Eugene NM, Robert LF (eds). Salivary gland disorders. Springer, Berlin

  22. Gonzalez-Garcia R, Rodriguez-Campo FJ et al (2005) Polymorphous low-grade adenocarcinoma of the palate: report of cases. Auris Nasus Larynx 32:275–280

    Article  PubMed  Google Scholar 

  23. Speight PM, Barrett AW (2002) Salivary gland tumors. Oral Dis 8:229–240

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

The authors are very grateful to Prof EEU Akang and Dr B Kolude of the departments of Pathology and Oral Pathology, respectively of the University College Hospital Ibadan for their various assistance in the management of the patient and preparation of this manuscript.

Conflict of interest

The author declare that no funding was received for this work and the authors have no special interest of any sort.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, University College Hospital, Ibadan, Nigeria

    A. A. Olusanya & V. I. Akinmoladun

  2. Department of Oral and Maxillofacial Surgery, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria

    O. A. Akadiri

  3. Department of Oral Pathology, University College Hospital, Ibadan, Nigeria

    B. F. Adeyemi

Authors
  1. A. A. Olusanya
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  2. O. A. Akadiri
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  3. V. I. Akinmoladun
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  4. B. F. Adeyemi
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Correspondence to A. A. Olusanya.

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Olusanya, A.A., Akadiri, O.A., Akinmoladun, V.I. et al. Polymorphous Low Grade Adenocarcinoma: Literature Review and Report of Lower Lip Lesion with Suspected Lung Metastasis. J. Maxillofac. Oral Surg. 10, 60–63 (2011). https://doi.org/10.1007/s12663-011-0185-1

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  • DOI: https://doi.org/10.1007/s12663-011-0185-1

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