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Preparation and Characterization of a Novel Nanocellulose-Derivative as a Potential Radiopharmaceutical Agent

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Abstract

Nanocellulose (NC) has a wide variety of emerging applications, including enzyme immobilization, drug delivery, and imaging diagnosis. On the other hand, derivatives of hydrazinonicotinic acid (HYNIC) have been used as coordination-agents for their binding to 99mTc in the development of potential radiopharmaceuticals. To this end, we studied and developed NC-HYNIC-99mTc for diagnostic imaging using NC obtained from rice husk using Trichoderma reseii and Phanaerochaete chrysosporium in a semi-solid fermentation system to generate a potential nanoradiopharmaceutical agent. In this work, we performed the separation of nanosilica, microcellulose, and nanocellulose using the TAPPI T203 os-74 technique. The synthesis of conjugate NC-HYNIC was performed following a one-pot procedure. The NC and the conjugate NC-HYNIC were characterized by Fourier Transform Infrared Spectroscopy (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and atomic force microscopy (AFM). We obtained NC with a structure of laminar-like nanofibers. The yield of NC was 55% and the conjugate NC-HYNIC was obtained with a yield of 36%. The TGA and FTIR analyses showed that the NC functionalized with HYNIC had similar characteristics to those of NC. In addition, the AFM analysis of the functionalized NC showed an average height of 8 ± 3 nm, while the NC showed an average height of 10 ± 4 nm. The subsequent binding to 99mTc was assayed, and the purity of the radiolabeled product and the efficiency of the process was studied by ITLC chromatography. The radiolabeling process was very efficient with a radiochemical purity of 98 ± 1.2%, which opens the possibility of a new potential-imaging agent.

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Acknowledgements

This work was supported by a scholarship ID 156 for Ph.D. student N.L from Comisión Sectorial de Investigación Científica (CSIC-Uruguay). The authors are grateful to Javier Villalobos and Sergio Paniagua for their technical support and useful discussions.

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Authors and Affiliations

  1. Laboratorio de Técnicas Nucleares Aplicadas a la Bioquímica y Biotecnología, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay

    Lecot Nicole, Gandaras Rosario & Lopretti Mary

  2. Grupo de Química Orgánica Medicinal, Facultad de Ciencias, Instituto de Química Biológica, Universidad de la República, Montevideo, Uruguay

    Gandaras Rosario & Cerecetto Hugo

  3. National Nanotechnology Laboratory, National Center for High Technology, 10109, Pavas, San José, Costa Rica

    Batista-Menezes Diego, Montes de Oca-Vásquez Gabriela & Vega-Baudrit José

  4. Laboratorio de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay

    Cabral Pablo, García Ma. Fernanda & Cerecetto Hugo

  5. Laboratory of Polymer Science and Technology, School of Chemistry, Universidad Nacional, Omar Dengo Campus, 86-3000, Heredia, Costa Rica

    Vega-Baudrit José

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  1. Lecot Nicole
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Nicole, L., Rosario, G., Diego, BM. et al. Preparation and Characterization of a Novel Nanocellulose-Derivative as a Potential Radiopharmaceutical Agent. Waste Biomass Valor 13, 173–183 (2022). https://doi.org/10.1007/s12649-021-01495-x

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