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DNA Damage in Major Psychiatric Diseases

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Abstract

Human cells are exposed to exogenous insults and continuous production of different metabolites. These insults and unwanted metabolic products might interfere with the stability of genomic DNA. Recently, many studies have demonstrated that different psychiatric disorders show substantially high levels of oxidative DNA damage in the brain accompanied with morphological and functional alterations. It reveals that damaged genomic DNA may contribute to the pathophysiology of these mental illnesses. In this article, we review the roles of oxidative damage and reduced antioxidant ability in some vastly studied psychiatric disorders and emphasize the inclusion of treatment options involving DNA repair. In addition, while most currently used antidepressants are based on the manipulation of the neurotransmitter regulation in managing different mental abnormalities, they are able to prevent or reverse neurotoxin-induced DNA damage. Therefore, it may be plausible to target on genomic DNA alterations for psychiatric therapies, which is of pivotal importance for future antipsychiatric drug development.

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Abbreviations

H2O2 :

Hydrogen peroxide

8-oxodG:

8-Oxo-7,8-dihydro-2′-dihydroguanosine

8-oxoGuo:

8-Oxo-7,8-dihydroguanosine

MDD:

Major depression disorder

mtDNA:

Mitochondrial DNA

NO:

Nitric oxide

RNS:

Reactive nitrogen species

ROS:

Reactive oxygen species

SOD:

Superoxide dismutase

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Acknowledgments

This work is supported by the NIH Grant MH080323.

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  1. Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, 37604, USA

    Muhammad Ummear Raza, Turan Tufan, Yan Wang, Christopher Hill & Meng-Yang Zhu

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Raza, M.U., Tufan, T., Wang, Y. et al. DNA Damage in Major Psychiatric Diseases. Neurotox Res 30, 251–267 (2016). https://doi.org/10.1007/s12640-016-9621-9

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