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Serum levels of CC chemokine ligands in cutaneous leishmaniasis patients

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Abstract

The crucial functions of chemokine/receptors in numerous parasitic infections, including leishmaniasis, are well documented. This study aimed to assess the serum levels of CC ligand (CCL) 2, CCL5, and CCL11 in cutaneous leishmaniasis (CL) patients. 64 patients, suffering from CL and 100 healthy people were selected, and their blood serum concentrations of CCL2, CCL5, and CCL11 were measured using enzyme-linked immunosorbent assay. The results demonstrated that while the mean serum levels of CCL5 and CCL11 increased significantly in CL patients, the mean serum levels of CCL2 decreased, compared to the control group. Despite the sufficient production of CCL5 and CCL11 in CL patients, they suffered from CCL2 deficiency, as the defense mechanism against parasitic infection. These findings suggest a mechanism that might partially explain the patients’ susceptibility to persistent infection and their inability to clear the parasites.

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Abbreviations

CCL:

Chemokine (C–C motif) ligand

CL:

Cutaneous leishmaniasis

CR3:

Complement receptor 3

CXCL:

Chemokine (C-X-C motif) ligand

DCL:

Diffuse cutaneous leishmaniasis

DL:

Disseminated leishmaniasis

ELISA:

Enzyme-linked immune-sorbent assay

ERK:

Extracellular signal-regulated kinase

FcRs:

Fc receptors

MR:

Mannose receptor

IFN:

Interferon

IL-12:

Interleukin-12

MAPK:

Mitogen-activated protein kinase

PBMC:

Peripheral blood mononuclear cell

SPSS:

Statistical package for the social sciences

Th1:

T helper 1

TNF:

Tumor necrosis factor

TLRs:

Toll-like receptors

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Acknowledgements

The authors would like to take this opportunity to thank all the participants who attended and cooperated in this research study.

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Authors and Affiliations

  1. Molecular Medicine Research Center, Rafsanjan University of Medical Sciences, P.O. Box 771751-735, Rafsanjan, Iran

    Gholamhossein Hassanshahi, Hossein Khorramdelazad, Zahra Ahmadi & Seyed Hossein Abdollahi

  2. Department of Immunology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Gholamhossein Hassanshahi

  3. School of Pharmacy, The University of Queensland, Woolloongabba, 4102, Australia

    Seyed Ebrahim Alavi

  4. Medical Parasitology and Mycology Department, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

    Ali Fattahi Bafghi

  5. Department of Microbiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Seyed Hossein Abdollahi & Hasan Ebrahimi Shahmabadi

Authors
  1. Gholamhossein Hassanshahi
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  2. Seyed Ebrahim Alavi
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  3. Hossein Khorramdelazad
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  4. Zahra Ahmadi
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  5. Ali Fattahi Bafghi
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  6. Seyed Hossein Abdollahi
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  7. Hasan Ebrahimi Shahmabadi
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Correspondence to Seyed Hossein Abdollahi or Hasan Ebrahimi Shahmabadi.

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Hassanshahi, G., Alavi, S.E., Khorramdelazad, H. et al. Serum levels of CC chemokine ligands in cutaneous leishmaniasis patients. J Parasit Dis 45, 153–158 (2021). https://doi.org/10.1007/s12639-020-01290-w

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  • DOI: https://doi.org/10.1007/s12639-020-01290-w

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