Abstract
Objective
To determine the oxidative balance and plasma fatty acid composition of overweight and obese women.
Design
Comparative, descriptive study on 60 overweight or obese (BMI 25–33 kg/m2), normotensive, nondiabetic women and 60 age-matched lean healthy women (BMI < 25 kg/m2).
Measurements
Plasma lipid, hydroperoxide, and antioxidants levels, fatty acid composition and the susceptibility of lipoproteins to peroxidation.
Results
Compared to the lean control group, the patient group had higher susceptibility of lipoproteins to peroxidation and higher peroxide levels. In contrast, the polyunsaturated fatty acids, in particular the ω-3 species, and the antioxidants were lower in the patient group.
Conclusions
The present study shows that overweight and obese people have oxidative balance impairment. The higher susceptibility of lipoproteins to peroxidation is the probable molecular mechanism that promotes a reduction in high unsaturated (and in particular ω-3) fatty acids, as well as antioxidants in the plasma of the overweight and obese subjects.
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Cazzola, R., Rondanelli, M., Trotti, R. et al. Oxidative state and lipid composition of plasma from overweight and moderately obese women. Mediterr J Nutr Metab 1, 19–24 (2008). https://doi.org/10.1007/s12349-008-0003-6
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DOI: https://doi.org/10.1007/s12349-008-0003-6