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Large retroperitoneal leiomyoma developed from the pelvic floor to the buttocks

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Abstract

Retroperitoneal leiomyoma is a very rare disease, with little reported information on its origin. Herein, we report a case of a large retroperitoneal leiomyoma that developed from the pelvic floor. A 44-year-old woman had a large mass protruding outside the body from the right hip. Imaging revealed a large tumor developing from the pelvic floor to the buttocks. It was difficult to identify the place of origin. Upon preoperative biopsy, the patient was diagnosed with retroperitoneal leiomyoma. Tumor removal with abdominoperineal and partial vaginal resection was performed. Based on the histological findings of the surgical specimens, she was diagnosed with a retroperitoneal leiomyoma (gynecologic type) via immunohistochemistry, the tumor cells were positive for αSMA, desmin, estrogen receptor(ER), and progesterone receptor(PgR), but negative for myoglobin, S-100, CD34, and MIB-1.This is a case of a large retroperitoneal leiomyoma that was successfully removed via abdominoperineal and partial vaginal resection.

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Abbreviations

CT:

Contrast-enhanced computed tomography

PET-CT:

Positron emission tomography-CT

18F-FDG:

Fluorodeoxyglucose

CEA:

Carcinoembryonic antigen

CA19-9:

Carbohydrate antigen 19–9

ER:

Estrogen receptor

PgR:

Progesterone receptor

References

  1. Rajiah P, Sinha R, Cuevas C, et al. Imaging of uncommon retroperitoneal masses. Radiographics. 2011;31:949–76.

    Article  Google Scholar 

  2. Nakashima J, Ueno M, Nakamura K, et al. Differential diagnosis of primary benign and malignant retroperitoneal tumors. Int J Urol. 1997;4:441–6.

    Article  CAS  Google Scholar 

  3. Egawa S, Satoh T, Suyama K, Uchida T, et al. Giant retroperitoneal cyst in an adult male. Int J Urol. 1996;3:304–6.

    Article  CAS  Google Scholar 

  4. Billings SD, Folpe AL, Weiss SW. Do leiomyomas of deep soft tissue exist? an analysis of highly differentiated smooth muscle tumors of deep soft tissue supporting two distinct subtypes. Am J Surg Pathol. 2001;25:1134–42.

    Article  CAS  Google Scholar 

  5. Fletcher CD, Bridge JA, Hogendoorn PCW, et al. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press; 2013.

    Google Scholar 

  6. Watanabe K, Tanaka M, Kusakabe T, et al. Mesometrial smooth muscle as an origin of female retroperitoneal (pelvic) leiomyomas. Virchows Arch. 2007;451:899–904.

    Article  Google Scholar 

  7. Peddada SD, Laughlin SK, Miner K, et al. Growth of uterine leiomyomata among premenopausal black and white women. Proc Natl Acad Sci USA. 2008;105:19887–92.

    Article  CAS  Google Scholar 

  8. Fasih N, Prasad Shanbhogue AK, Macdonald DB, et al. Leiomyomas beyond the uterus: unusual locations, rare manifestations. Radiographics. 2008;28:1931–48.

    Article  Google Scholar 

  9. Arleo EK, Schwartz PE, Hui P, et al. Review of leiomyoma variants. AJR Am J Roentgenol. 2015;205:912–21.

    Article  Google Scholar 

  10. Karray O, Boulma R, Abdi A, et al. Management of a giant retroperitoneal leiomyoma: a case report. J Med Case Rep. 2018;12:81.

    Article  CAS  Google Scholar 

  11. Schnapauff D, Russ M, Kröncke T, et al. Analysis of presurgical uterine artery embolization (PUAE) for very large uterus myomatosus; patient’s desire to preserve the uterus; case series and literature review. RöFo-Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren. 2018;190:616–22.

    Article  Google Scholar 

  12. Chrisman HB, West D, Corpuz B, et al. Primary failure of uterine artery embolization: use of magnetic resonance imaging to select patients for repeated embolization. J Vast Interv Radiol. 2005;16:1143–7.

    Article  Google Scholar 

  13. Weiss SW, Goldblum JR. Enzinger and Weiss’s soft tissue tumors. 5th ed. Philadelphia: Mosby Elsevier; 2008.

    Google Scholar 

  14. Paal E, Miettinen M. Retroperitoneal leiomyomas: a clinicopathologic and immunohistochemical study of 56 cases with a comparison to retroperitoneal leiomyosarcomas. Am J Surg Pathol. 2001;25:1355–63.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Enago (www.enago.jp) for the English language review.

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Authors and Affiliations

  1. Department of General Surgical Science, Graduate School of Medicine, Gunma University, 3-39-22, Showa-machi, Maebashi Gunma, 371-8511, Japan

    Yoko Motegi, Hiroomi Ogawa, Kohei Tateno, Kunihiko Suga, Takuhisa Okada, Katsuya Osone, Ryuji Katoh, Kyoichi Ogata, Makoto Sakai, Makoto Sohda, Ken Shirabe & Hiroshi Saeki

  2. Clinical Department of Pathology, Gunma University Hospital, 3-39-15, Showa-machi, Maebashi Gunma, 371-8511, Japan

    Makoto Sohda

  3. Department of Oral, Maxillofacial Surgery, and Plastic Surgery, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi Gunma, 371-8511, Japan

    Takaya Makiguchi

Authors
  1. Yoko Motegi
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  2. Hiroomi Ogawa
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  3. Kohei Tateno
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  4. Kunihiko Suga
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  5. Takuhisa Okada
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  6. Katsuya Osone
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  7. Ryuji Katoh
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  8. Kyoichi Ogata
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  9. Makoto Sakai
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  10. Makoto Sohda
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  11. Takaya Makiguchi
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  12. Ken Shirabe
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  13. Hiroshi Saeki
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Contributions

All authors contributed to the study conception and design. HO and KT conceived the case presentation and drafted the manuscript. HO, KS, TO, KO, RK, KO, and TM participated in the treatment of the patient. HI determined the pathological diagnosis of the patient. MS, KS and HS revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Makoto Sohda.

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The authors declare that they have no conflict of interest.

Human/animal rights

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

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Informed consent was obtained from the patient included in the study.

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Motegi, Y., Ogawa, H., Tateno, K. et al. Large retroperitoneal leiomyoma developed from the pelvic floor to the buttocks. Clin J Gastroenterol 14, 1169–1174 (2021). https://doi.org/10.1007/s12328-021-01436-0

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  • DOI: https://doi.org/10.1007/s12328-021-01436-0

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