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Primary synovial sarcoma of the mediastinum: a rare tumor diagnosed by endoscopic ultrasound-fine needle biopsy (EUS-FNB)—Cytomorphologic, immunohistochemical, and molecular analysis

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Abstract

Primary synovial sarcoma is exceedingly rare in the mediastinum. The differential diagnosis of this rare tumor is complex as a wide array of primary and metastatic tumors occur in this site.

A definite diagnosis might be challenging even after tissue sampling. Immunohistochemistry can be very helpful and supportive for the diagnosis, but still inadequate in some cases as these tumors can mimic histopathologically other soft tissue tumors. Hence, in some case, an advanced pathological molecular analysis is needed.

Endoscopic ultrasound (EUS) is an important diagnostic tool for mediastinal tumors. While EUS-fine needle aspiration (EUS-FNA) samples are usually inadequate for advanced pathological analysis, tissue acquisition by the newer generation of EUS-fine needle biopsy (EUS-FNB) needles might be sufficient.

Here, we present the first report on primary mediastinal synovial sarcoma diagnosed by an immunohistochemical and FISH analysis performed on EUS-FNB tissue sample.

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Authors and Affiliations

  1. The Ruth and Bruce Rappaport Faculty of Medicine, Technion—Israel Institute of Technology, POB 9602, 31096, Haifa, Israel

    Iyad Khamaysi

  2. Invasive Endoscopy Unit, Department Gastroenterology and Hepatology, Rambam Health Care Campus, Haifa, Israel

    Iyad Khamaysi

  3. Department of Pathology, Rambam Health Care Campus, Haifa, Israel

    Inna Naroditsky & Leonid Malkin

Authors
  1. Iyad Khamaysi
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  2. Inna Naroditsky
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  3. Leonid Malkin
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Correspondence to Iyad Khamaysi.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all patients for being included in the study.

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Khamaysi, I., Naroditsky, I. & Malkin, L. Primary synovial sarcoma of the mediastinum: a rare tumor diagnosed by endoscopic ultrasound-fine needle biopsy (EUS-FNB)—Cytomorphologic, immunohistochemical, and molecular analysis . Clin J Gastroenterol 14, 961–964 (2021). https://doi.org/10.1007/s12328-021-01393-8

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  • DOI: https://doi.org/10.1007/s12328-021-01393-8

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