Abstract
A 78-year-old man who underwent right nephrectomy for renal cell carcinoma (RCC) 18 years ago visited our hospital complaining of abdominal pain. Imaging revealed that the pancreatic head tumor obstructed the Santorini duct. We suspected a pancreatic intraductal tumor, such as an intraductal tubulopapillary neoplasm or intraductal papillary mucinous neoplasm. Thus, the patient underwent subtotal stomach-preserving pancreaticoduodenectomy. Pathological findings confirmed the diagnosis of metastatic RCC. Herein, we report a case of pancreatic metastasis of an RCC that presented with a tumor in the pancreatic duct.
Similar content being viewed by others
References
Comunoglu C, Altaca G, Dmiralay E, et al. Multiple metastatic renal cell carcinoma isolated to pancreas. Lancet Oncol. 2012;10:287–93.
Ballarin R, Spaggiari M, Cautero N, et al. Pancreatic metastases from renal cell carcinoma: the state of the art. World J Gastroenterol. 2011;17:4747–56.
Kassabian A, Stein J, Jabbour N, et al. Renal cell carcinoma metastatic to the pancreas: a single-institution series and review of the literature. Urology. 2000;56:211–5.
Ghavamian R, Klein KA, Stephens DH, et al. Renal cell carcinoma metastatic to the pancreas: clinical and radiological features. Mayo Clin Proc. 2000;75:581–5.
Faure JP, Tuech JJ, Richer JP, et al. Pancreatic metastasis of renal cell carcinoma: presentation, treatment and survival. J Urol. 2001;165:20–2.
Braufau BP, Cerqueda CS, Villalba LB, et al. Metastatic renal cell carcinoma: radiologic findings and assessment of response to targeted antiangiogenic therapy by using multidetector CT. Radiographics. 2013;33:1691–716.
Yachida S, Fukushima N, Kanai Y, et al. Pancreatic metastasis from renal cell carcinoma extending into the main pancreatic duct: a case report. J Clin Oncol. 2002;32:315–7.
Hijioka S, Hifumi M, Mekky MA, et al. Total Pancreatectomy for metastatic reanal cell carcinoma with marked extension into the main pancreatic duct. Inter Med. 2010;49:557–62.
Fabre JM, Rouanet P, Dagues F, et al. Various features and surgical approach of solitary pancreatic metastasis from renal cell carcinoma. Eur J Surg Oncol. 1995;21:683–6.
Abbas MA, Collins JM, Mulligan DC. Renal cell carcinoma metastatic to pancreas. AM J Surg. 2001;182:183–4.
Reddy S, Wolfgang CL. The role of surgery in the management of isolated metastases to the pancreas. Lancet Oncol. 2009;10:287–93.
Klugo RC, M Detmers, Stiles RE, et al. Aggressive versus conservative management of Stage IV renal cell carcinoma. J Urol. 1977;118:244–6.
Schauer M, Vogelsang H, Siewert JR. Pancreatic resection for metastatic renal cell carcinoma: a single center experience and review of the literature. Anticancer Res. 2008;28:361–5.
Benhaim R, Oussoultzoglou E, Saeedi Y, et al. Pancreatic metastasis from clear cell carcinoma: outcome of an aggressive approach. Urology. 2015;85:135–40.
Thompson LD, Heffess CS. Renal cell carcinoma to the pancreas in surgical pathology material. Cancer. 2000;89:1076–88.
Strijk SP. Pancreatic metastasis of renal cell carcinoma; report of two cases. Gastrointest Radiol. 1989;14:123–6.
Wente MN, Kleef J, Esposito I, et al. Renal cancer cell metastases in to the pancreas. A single-center experience and overview of the literature. Pancreas. 2005;30:218–22.
M Habu, R Hosotani, A Miki, at al. Pancreatic metastasis from renal cell carcinoma: a review of 13 cases. Jpn Gastroenterol Surg. 2012;45:1331–138.
Klugo RC, Detmers M, Stiles RE, et al. Aggressive versus conservative management of Stage IV renal cell carcinoma. J Urol. 1977;118:244–6.
Sellner F, Tykalsky N, Santis MD, et al. Solitary and multiple isolated metastases of clear cell renal carcinoma to the pancreas: an indication for pancreatic surgery. Ann Surg Oncol. 2006;13:75–85.
Acknowledgement
This work supported by JSPS KAKENHI Grant Number JP 19K07938 (A.S.).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
Yasutaka Yamada, Arata Sakai, Shohei Abe, Masanori Gonda, Takashi Kobayashi, Atsuhiro Masuda, Hideyuki Shiomi,Sachiyo Shirakawa, Hirochika Toyama, Toshiki Hyodo, Maki Kanzawa, Tomoo Itoh, and Yuzo Kodama declare that they have no conflict of interest.
Human/animal rights
All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
Informed consent
Informed consent was obtained from all patients for being included in the study.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Yamada, Y., Sakai, A., Abe, S. et al. Pancreatic metastasis of renal cell carcinoma filling into the duct of Santorini. Clin J Gastroenterol 14, 905–909 (2021). https://doi.org/10.1007/s12328-021-01369-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12328-021-01369-8