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Simultaneous macroamylasemia and macrolipasemia in a patient with mucosa-associated lymphoid tissue lymphoma

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Abstract

We report a case of simultaneous macroamylasemia and macrolipasemia complicated with mucosa-associated lymphoid tissue (MALT) lymphoma. A 78-year-old man presented with hyperamylasemia and hyperlipasemia for 2 years and was misdiagnosed with chronic pancreatitis at another hospital. However, his other pancreatic enzymes were normal, his amylase-creatinine clearance ratio was low, and no definite findings of pancreatic disease were evident. Immunological analyses revealed that both amylase and lipase were bound to immunoglobulin (Ig) A-κ, and that serum IgA was high (827.1 mg/dL). He was diagnosed with simultaneous macroamylasemia and macrolipasemia. Since these diseases are associated with malignancy, an additional investigation was performed which revealed the complication of MALT lymphoma, and polymerase chain reaction analysis showed monoclonal immunoglobulin light chain gene rearrangement (κ >> λ). In this case, macroamylasemia and macrolipasemia may have developed due to the formation of macroenzymes resulting from excess IgA-κ secreted by the MALT lymphoma. Simultaneous macroamylasemia and macrolipasemia are very rare and difficult to diagnose and can lead to diagnostic and therapeutic errors. When encountering atypical clinical features associated with hyperamylasemia and hyperlipasemia, the possibility of macroenzymes and underlying diseases such as lymphoproliferative disorders should be considered.

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Authors and Affiliations

  1. Department of Gastroenterology, Toranomon Hospital and Okinaka Memorial Institute for Medical Research, 2-2-2 Toranomon, Minato-ku, Tokyo, 105-0001, Japan

    Nobuhiko Ogasawara, Tsunao Imamura, Yoshiki Sato, Tetsuo Tamura, Yuji Urasaki, Yuko Kono & Rikako Koyama

  2. Department of Pathology, Toranomon Hospital, Tokyo, Japan

    Naoko Inoshita

  3. Department of Hematology, Toranomon Hospital, Tokyo, Japan

    Aya Nishida

Authors
  1. Nobuhiko Ogasawara
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  2. Tsunao Imamura
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  3. Yoshiki Sato
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  4. Tetsuo Tamura
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  5. Yuji Urasaki
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  6. Yuko Kono
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  7. Rikako Koyama
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  8. Naoko Inoshita
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  9. Aya Nishida
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Corresponding author

Correspondence to Tsunao Imamura.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from the patient for being included in this case report.

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Ogasawara, N., Imamura, T., Sato, Y. et al. Simultaneous macroamylasemia and macrolipasemia in a patient with mucosa-associated lymphoid tissue lymphoma. Clin J Gastroenterol 13, 626–631 (2020). https://doi.org/10.1007/s12328-019-01090-7

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  • DOI: https://doi.org/10.1007/s12328-019-01090-7

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