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Association between Crohn’s disease and AarF domain-containing kinase 4 glomerulopathy

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Abstract

Coenzyme Q10 deficiency causing gastrointestinal symptoms has not been reported. At least 15 genes are involved in CoQ10 biosynthesis, and one of the genes is AarF domain-containing kinase 4 (ADCK4). This case report first showed a patient who presented with Crohn’s disease (CD) combined with ADCK4 glomerulopathy (ADCK4-GN). After approximately 2 years of infliximab treatment for CD, this patient has remained in clinical remission with no adverse effects. Moreover, two important findings were obtained: first, individuals with ADCK4-GN may present with complications, such as CD, which is a gastrointestinal disease, and infliximab may be effective for CD associated with ADCK4-GN. Second, infliximab may also be effective and safe for individuals with CD who are undergoing peritoneal dialysis. Thus, the results of the present study may be used in managing patients with such condition, and as a result, better clinical outcomes will be obtained.

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Acknowledgements

The authors would like to thank the patient’s family for consenting and allowing them to write and publish this case report.

Funding

No financial supports.

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Authors and Affiliations

  1. Department of Pediatrics, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga-shi, Saga, 849-8501, Japan

    Toshihiko Kakiuchi, Yasufumi Ohtsuka, Aiko Nakayama, Kumiko Jinnouchi & Muneaki Matsuo

  2. Department of Pediatrics, Ureshino Medical Center, 2436, Shimojuku-hei, Oaza, Ureshino-machi, Ureshino-shi, Saga, 843-0393, Japan

    Tadashi Sato & Masafumi Oka

Authors
  1. Toshihiko Kakiuchi
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  2. Yasufumi Ohtsuka
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  3. Tadashi Sato
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  4. Aiko Nakayama
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  5. Kumiko Jinnouchi
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  6. Masafumi Oka
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  7. Muneaki Matsuo
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Contributions

As the lead author, TK was involved with all stage of patient management and wrote the manuscript. YO, TS, AN, KJ and MO performed the treatment. MM collaborated as the reviewer. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Toshihiko Kakiuchi.

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Conflict of interest

Kakiuchi T, Ohtsuka Y, Sato T, Nakayama A, Jinnouchi K, Oka M and Matsuo M declare that they no conflict of interest.

Human/animal rights

All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Informed consent

Informed consent was obtained from all patients for being included in the study.

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Kakiuchi, T., Ohtsuka, Y., Sato, T. et al. Association between Crohn’s disease and AarF domain-containing kinase 4 glomerulopathy. Clin J Gastroenterol 12, 263–268 (2019). https://doi.org/10.1007/s12328-019-00937-3

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  • DOI: https://doi.org/10.1007/s12328-019-00937-3

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