Skip to main content

Advertisement

Log in

A case of IgG4-related disease associated with diffuse large B cell lymphoma

  • Case Report
  • Published:
Clinical Journal of Gastroenterology Aims and scope Submit manuscript

Abstract

In June 2008, a 74-year-old male was diagnosed with IgG4-related disease including histologically proven IgG4-related prostatitis, and then followed as an outpatient. In July 2011, cervical, chest, and abdominal computed tomography (CT) revealed right parotid gland swelling and lymph node enlargement of the supraclavicular, mediastinal, left hilar, porta hepatis, and para-aorta. A biopsy of the right parotid gland was performed, and we diagnosed diffuse large B-cell lymphoma (DLBCL). As malignancies are possible complications for patients with IgG4-related disease, we must be careful in the follow-up of IgG4-related disease patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Masaki Y, Kurose N, Umehara H, et al. IgG4-related disease: a novel lymphoproliferative disorder discovered and established in Japan in the 21st century. J Clin Exp Hematopathol. 2011;51(1):13–20.

    Article  Google Scholar 

  2. Umehara H, Okazaki K, Masaki Y, Kuwano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H, Inui K, Ohara H, et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol. 2012;22(1):21–30.

    Google Scholar 

  3. Fukui T, Mitsuyama T, Takaoka M, Uchida K, Matsusita M, Okazaki K, et al. Pancreatic cancer associated with autoimmune pancreatitis in remission. Intern Med. 2007;47:151–5.

    Article  Google Scholar 

  4. Raffaele Pezzilli, Silvia Veccchiarelli, Maria Cristina Di Marco, Carla Serra, Donatella Santini, Lucia Calclli, Dario Fabbri, Betzabe Rojas Mena, Andrea Imbrogno, et al. Pancreatic ductal adenocarcinoma associated with autoimmune pancreatitis. Case Rep Gastroenterol. 2011;5(2):378–385.

  5. Gill J, Angelo N, Young ML, McIvor N, et al. Salivary duct carcinoma arising in IgG4-related autoimmune disease of the parotid gland. Hum Pathol. 2009;40(6):761–5.

    Article  Google Scholar 

  6. Straub BK, Esposito I, Gotthardt D, Radeleff B, Antolovic D, Flechtenmacher C, et al. IgG4-associated cholangitis with cholangiocarcinoma. Virchows Arch. 2011;458(6):761–5.

    Article  PubMed  Google Scholar 

  7. Cheuk W, Yuen HK, Chan AC, et al. Ocular adnexal lymphoma associated with IgG4+ chronic sclerosing dacryoadenitis: a previously undescribed complication of IgG4-related sclerosing disease. Am J Surg Pathol. 2008;32:1159–67.

    Article  PubMed  Google Scholar 

  8. Takahashi N, Ghazale AH, Smyrk TC, Mandrekar JN, Chari ST, et al. Possible association between IgG4-associated systemic disease with or without autoimmune pancreatitis and non-Hodgkin lymphoma. Pancreas. 2009;38:523–6.

    Article  PubMed  Google Scholar 

  9. Kanda G, Ryu T, Shirai T, Ijichi M, Hishima T, Kitamura S, Bandai Y, et al. Peripheral T-cell lymphoma that developed during the follow-up of IgG4-related disease. Intern Med. 2011;50:155–60.

    Article  PubMed  Google Scholar 

  10. Yamamoto M, Takashi H, Tabeya T, Suzuki C, Nashiro Y, Ishigami K, et al. Risk of malignancies in IgG4-related disease. Mod Rheumatol. 2012;22(3):414–8.

    Google Scholar 

  11. Zintzaras E, Voulgarelis M, Moutsopoulos HM, et al. The risk of lymphoma development in autoimmune disease: a meta-analysis. Arch Intern Med. 2005;165:2337–44.

    Article  PubMed  Google Scholar 

  12. Smedby KE, Baecklund E, Askling J, et al. Malignant lymphoma in autoimmunity and inflammation: a review of risks, risk factors, and lymphoma characteristics. Cancer Epidemiol Biomarkers Prev. 2006;15:2068–77.

    Article  Google Scholar 

  13. Zhang W, Feng S, Yan S, Zhao Y, Li M, Sun J, et al. Incidence of malignancy in primary Sjogren’s syndrome in Chinese cohort. Rheumatology (Oxford). 2010;49:571–7.

    Article  Google Scholar 

  14. Hansen A, Lipsky PE, Dorner T, et al. B-cell lymphoproliferation in chronic inflammatory rheumatic disease. Nat Clin Pract Rheumatol. 2007;3:561–9.

    Article  PubMed  CAS  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kazuichi Okazaki.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mitsuyama, T., Nishio, A., Takaoka, M. et al. A case of IgG4-related disease associated with diffuse large B cell lymphoma. Clin J Gastroenterol 6, 63–68 (2013). https://doi.org/10.1007/s12328-012-0345-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12328-012-0345-y

Keywords

Navigation