Abstract
A 53-year-old man was referred to our hospital with bloody stool. Barium enema study and colonoscopy revealed multiple small nodules on the anterior wall of the lower rectum. Biopsy specimens showed proliferation of atypical lymphoid cells forming the nodules. Mucosa-associated lymphoid tissue lymphoma was diagnosed on the basis of histologic and immunohistochemical examinations. No metastasis was detected in lymph nodes or distant organs, indicative of clinical stage I disease. Although the test results were negative for Helicobacter pylori, eradication therapy was performed. The lesion disappeared completely within 9 months after the triple antibiotic therapy. H. pylori eradication therapy may be a useful treatment option regardless of H. pylori status.
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References
Isaacson PG. Mucosa-associated lymphoid tissue lymphoma. Semin Hematol. 1999;36:139–47.
Isaacson PG. Gastrointestinal lymphomas of T- and B-cell types. Mod Pathol. 1999;12:151–8.
Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342:575–7.
Wotherspoon AC. Helicobacter pylori infection and gastric lymphoma. Br Med Bull. 1998;54:79–85.
Wotherspoon AC. Gastric lymphoma of mucosa-associated lymphoid tissue and Helicobacter pylori. Annu Rev Med. 1998;49:289–99.
Romaguera J, Hagemeister FB. Lymphoma of the colon. Curr Opin Gastroenterol. 2005;21:80–4.
Ahlawat S, Kanber Y, Charabaty-Pishvaian A, et al. Primary mucosa-associated lymphoid tissue (MALT) lymphoma occurring in the rectum: a case report and review of the literature. South Med J. 2006;99:1378–84.
Tanaka S, Ohta T, Kaji E, et al. EMR of mucosa-associated lymphoid tissue lymphoma of the rectum. Gastrointest Endosc. 2003;57:956–9.
Grunberger B, Wohrer S, Streubel B, et al. Antibiotic treatment is not effective in patients infected with Helicobacter pylori suffering from extragastric MALT lymphoma. J Clin Oncol. 2006;24:1370–5.
Matsumoto T, Iida M, Shimizu M. Regression of mucosa-associated lymphoid-tissue lymphoma of rectum after eradication of Helicobacter pylori. Lancet. 1997;350:115–6.
Matsumoto T, Shimizu M, Iida M, et al. Primary low-grade, B-cell, mucosa-associated lymphoid tissue lymphoma of the colorectum: clinical and colonoscopic features in six cases. Gastrointest Endosc. 1998;48:501–8.
Inoue F, Chiba T. Regression of MALT lymphoma of the rectum after anti-H. pylori therapy in a patient negative for H. pylori. Gastroenterology. 1999;117:514–5.
Niino D, Yamamoto K, Tsuruta O, et al. Regression of rectal mucosa-associated lymphoid tissue (MALT) lymphoma after antibiotic treatments. Pathol Int. 2010;60:438–42.
Hisabe T, Imamura K, Furukawa K, et al. Regression of CD5-positive and Helicobacter pylori-negative mucosa-associated lymphoid tissue lymphoma of the rectum after administration of antibiotics: report of a case. Dis Colon Rectum. 2002;45:1267–70.
Nakase H, Okazaki K, Ohana M, et al. The possible involvement of micro-organisms other than Helicobacter pylori in the development of rectal MALT lymphoma in H. pylori-negative patients. Endoscopy. 2002;34:343–6.
Hori K, Suguro M, Koizuka H, et al. Disappearance of rectal mucosa-associated lymphoid tissue lymphoma following antibiotic therapy. Dig Dis Sci. 2004;49:413–6.
Kikuchi Y, Matsui T, Hisabe T, et al. Deep infiltrative low-grade MALT (mucosal-associated lymphoid tissue) colonic lymphomas that regressed as a result of antibiotic administration: endoscopic ultrasound evaluation. J Gastroenterol. 2005;40:843–7.
Ahlawat S, Haddad N, Kanber Y, et al. Primary mucosa-associated lymphoid tissue lymphoma occurring in the rectum. Gastrointest Endosc. 2005;62:443–4. (discussion 444).
Dohden K, Kaizaki Y, Hosokawa O, et al. Regression of rectal mucosa-associated lymphoid tissue lymphoma but persistence of Helicobacter pylori infection of gastric mucosa after administration of levofloxacin: report of a case. Dis Colon Rectum. 2004;47:1544–6.
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Ohara, E., Kitadai, Y., Onoyama, M. et al. Regression of rectal MALT lymphoma after antibiotic treatment in a patient negative for Helicobacter pylori . Clin J Gastroenterol 5, 59–63 (2012). https://doi.org/10.1007/s12328-011-0270-5
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DOI: https://doi.org/10.1007/s12328-011-0270-5