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Effect of Anti-CMV Therapy at Different Stages on Retinal Detachment in Patients with AIDS and CMVR

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Abstract

Introduction

The present study aimed to investigate the effect of anti-cytomegalovirus (anti-CMV) therapy at different stages on retinal detachment in patients with acquired immunodeficiency syndrome (AIDS) and cytomegalovirus retinitis (CMVR).

Methods

Ninety-seven patients with AIDS and CMVR diagnosed and treated at the Ophthalmology and Infection Center of Beijing You’an Hospital, affiliated with Capital Medical University, from November 2017 to January 2020 were retrospectively analyzed. Of the 138 eyes included, 30 eyes with concomitant retinal detachment were enrolled as the study subjects. The eyes with retinal detachment were divided into a pre-induction group, an intra-induction group, and a post-induction group of anti-CMV therapy. The occurrence and characteristics of retinal detachment at different stages of anti-CMV therapy were observed.

Results

Retinal detachment occurred in 30 of the 138 eyes of 97 patients, with an incidence of retinal detachment of 21.74%. Retinal detachment occurred in eight eyes in the pre-induction group, with an incidence of 26.67%, and in four eyes in the intra-induction group, with an incidence of 13.33%. The difference in incidence between the two groups was statistically significant (P = 0.000). Retinal detachment occurred in 18 eyes in the post-induction group, with an incidence of 60%. The difference in incidence between the intra-induction group and the post-induction group was statistically significant (P = 0.001).

Conclusion

The incidence of retinal detachment at the intra-induction stages of anti-CMV therapy was lower than that at the pre-induction stage, and retinal detachment during the anti-CMV therapy predominantly occurred after the end of the induction stage.

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Acknowledgements

We thank the participants of the study.

Funding

This study and the journal’s rapid service fee was supported by the Scientific Research Project of Beijing YouAn Hospital, CCMU, 2018 (YNKTQN20180201). The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosures

Lian-Yong Xie, Chao Chen, Wen-Jun Kong, Tai-Yi Jiang, Kui-Fang Du, Hong-Wei Dong, Chun-Gang Guo, Xiao-Na Li and Wen-Bin Wei have nothing to disclose.

Compliance with Ethics Guidelines

This study was conducted with approval from the Ethics Committee of Beijing YouAn Hospital, Capital Medical University (LL-2018-150-K). This study was performed in accordance with the Helsinki Declaration of 1964 and its later amendments. Written informed consent to participate and publication was obtained from all participants.

Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Author notes

  1. Lian-Yong Xie and Chao Chen contributed equally to this study.

Authors and Affiliations

  1. Department of Ophthalmology, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China

    Lian-Yong Xie, Chao Chen, Wen-Jun Kong, Kui-Fang Du, Hong-Wei Dong, Chun-Gang Guo & Xiao-Na Li

  2. Department of Infectious Diseases, Beijing YouAn Hospital, Capital Medical University, Beijing, 100069, China

    Tai-Yi Jiang

  3. Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China

    Wen-Bin Wei

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  1. Lian-Yong Xie
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Correspondence to Wen-Bin Wei.

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Xie, LY., Chen, C., Kong, WJ. et al. Effect of Anti-CMV Therapy at Different Stages on Retinal Detachment in Patients with AIDS and CMVR. Adv Ther 38, 2294–2301 (2021). https://doi.org/10.1007/s12325-021-01674-1

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  • DOI: https://doi.org/10.1007/s12325-021-01674-1

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