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Correlation of Microalbuminuria with Estimated GFR (eGFR) by Cockcroft–Gault and MDRD Formula in Type 2 Diabetics and Hypertensives

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Abstract

Increase in urine albumin excretion rate (AER) precede a fall in glomerular filtration rate in patients developing diabetic chronic kidney disease (CKD). Our results have shown that 7 (50 %) of diabetic and hypertensive individuals with decreased GFR do not have increased AER. In this cross-sectional study, we measured AER of 75 patients with type 2 diabetes and hypertension by immunoturbidimetric method. We correlated the results with eGFR values obtained by Cockcroft–Gault and MDRD method. The method used was not a compensated method. We measured serum creatinine by modified Jaffe’s kinetic method in autoanalyzer XL-600. Analysis of data showed positive correlation between eGFR and microalbuminuria by both the methods with eGFR <60 mL/min/1.73 m2. Pearson’s correlation co-efficient (r) was 0.9 (p = 0.0001) by Cockcroft–Gault formula and 0.69 (p = 0.0063) by MDRD formula. Our results concluded that there was positive correlation between AER and eGFR <60 mL/min/1.73 m2. We have recognized that these two parameters provide a complimentary benefit in management of cases with CKD.

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The study did not receive any specific grant from any funding agency in public, commercial or not-for-profit sector.

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Authors and Affiliations

  1. Department of Biochemistry, Armed Forces Medical College (AFMC), Pune, 411040, Maharashtra, India

    T. K. Saha, Arabinda Mohan Bhattarai, H. S. Batra, Mithu Banerjee, Pratibha Misra & Vivek Ambade

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  1. T. K. Saha
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  2. Arabinda Mohan Bhattarai
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  3. H. S. Batra
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  4. Mithu Banerjee
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  5. Pratibha Misra
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  6. Vivek Ambade
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Correspondence to T. K. Saha.

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Saha, T.K., Bhattarai, A.M., Batra, H.S. et al. Correlation of Microalbuminuria with Estimated GFR (eGFR) by Cockcroft–Gault and MDRD Formula in Type 2 Diabetics and Hypertensives. Ind J Clin Biochem 30, 271–274 (2015). https://doi.org/10.1007/s12291-014-0439-z

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  • DOI: https://doi.org/10.1007/s12291-014-0439-z

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