Skip to main content
SpringerLink
Log in

Hematological Parameters and RBC TBARS Level of Q 10 Supplemented Tribal Sickle Cell Patients: A Hospital Based Study

  • Original Article
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

The study has been undertaken as number of sickle cell patients in Chhattisgarh tribal population is 23.7 %. The Co enzyme Q10 is a strong antioxidant and energy producing compound. The patients were divided into three groups group A homozygous (SS), group B heterozygous (AS) and group C controls for TBARS study. The age group is 10–55 years and 200 mg of CoQ10 was given to A and B groups. The hematological parameters, C reactive protein as well as RBC TBARS level were performed by usual and standard techniques. The results were obtained as 25.37 % increased RBC level in group A and 23.24 % in group B. The increased hemoglobin level was observed as 16.73 % in group A and 10.7 % in group B. In case of WBC it was observed increased 24.38 % in group A and 12.0 % in group B. C-reactive protein was observed 7.8 times decreased in group A and 1.54 times in group B. The RBC TBARS level was also found decreased 48 % in group A and 51 % in group B as compared to group C. During the supplementation of coenzyme Q10 the pain caused by vaso-occlusive events has reduced. This significant increase in hematological parameters as well as decreased C-reactive protein and TBARS level suggest that the Q10 should be included in the diet of sickle cell patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Nath KA, Grande JP, Haggard JJ, et al. Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease. Am J Pathol. 2001;158(3):893–903.

    Article  PubMed  CAS  Google Scholar 

  2. Hebbel RP. Special issue of microcirculation: examination of the vascular pathology of sickle cell anemia. Microcirculation. 2004;11(2):99–100.

    PubMed  Google Scholar 

  3. Wood Katherine C, Neil Granger D. Sickle cell disease: role of reactive oxygen and nitrogen metabolites. Clin Exp Pharmacol Physiol. 2007;34(9):926–32.

    Article  PubMed  CAS  Google Scholar 

  4. Michael B. Schachter, M.D. 1996. Available from. http://www.mbschachter.com/coenzyme q10.htm.

  5. Gian Paolo Littarru. Energy and defense. Facts and perspectives on Coenzyme Q10 In biology and medicine, Casa Editrice Scientifica Internazionale; Italy, 1994.P.21.

  6. Gian Paolo Littarru. Energy and Defense. Facts and perspectives on Coenzyme Q10 In biology and medicine, Casa Editrice Scientifica Internazionale; Italy, 1994.P.22.

  7. Littarru GP, Battino M, Tomasetti M, Mordente A, Santini S, Oradei A, Manto A, Ghirlanda G. Metabolic implications of coenzyme Q10 in red blood cells and plasma lipoproteins. Mol Aspects Med. 1994;15(Suppl):s67–72.

    Article  PubMed  CAS  Google Scholar 

  8. Rice-Evans Catherine, Omorphos SavvasC, Baysal Erol. Sickle cell membranes and oxidative damage. Biochem J. 1986;237(1):265–9.

    PubMed  CAS  Google Scholar 

  9. Manfredini V, Lazzaretti LL, Griebeter IH, Santin AP, Brandao VD, Wagner S, Castro SM, Peralba Mdo C, Benfato MS. Blood antioxidant parameters in sickle cell anemia patients in steady state. J Natl Med Assoc. 2008;100(8):897–902.

    PubMed  Google Scholar 

  10. Amer Johnny, Ghoti Hussam, Rachmilewitz Eliezer, Koren Ariel, Kevin Carina, Fibach Eitan. Red blood cells, platelets and polymorphonuclear neutrophils of patients with sickle cell disease exhibit oxidative stress that can be ameliorated by antioxidants. Br J Haematol. 2006;132(1):108–13.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

Thanks to Pharma Nord, Denmark for providing Q10 sample and thanks to Chhattisgarh Council of Science and Technology, Raipur, India for its financial support.

Author information

Authors and Affiliations

  1. Department of Biochemistry, Government Medical College, Jagdalpur, CG, 494 001, India

    A. S. Thakur

  2. Institute of Biochemistry, University of Ancona, Via Rameri, Ancona, Italy

    G. P. Littaru

  3. Production and Research Pharma Nord, Sadelmagervej 30-32, 7100, Vejle, Denmark

    S. Moesgaard

  4. Research Department, Sadelmagervej 30-32, 7100, Vejle, Denmark

    C. Dan sindberg

  5. Department of Medicine, Chhattisgarh Institute of Medical Sciences, Bilaspur, CG, India

    Y. Khan

  6. Department of Community Medicine, RIMS, Saifay, Etawah, U.P., India

    C. M. Singh

Authors
  1. A. S. Thakur
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. P. Littaru
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Moesgaard
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Dan sindberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Y. Khan
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. M. Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. S. Thakur.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thakur, A.S., Littaru, G.P., Moesgaard, S. et al. Hematological Parameters and RBC TBARS Level of Q 10 Supplemented Tribal Sickle Cell Patients: A Hospital Based Study. Ind J Clin Biochem 28, 185–188 (2013). https://doi.org/10.1007/s12291-012-0277-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-012-0277-9

Keywords

Search

Navigation