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Antidyslipidemic and Antioxidant Activities of Hibiscus rosa sinensis Root Extract in Alloxan Induced Diabetic Rats

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Abstract

The antidyslipidemic activity of Hibiscus rosa sinensis (Malvaceae) root extract has been studied in alloxan induced diabetic rats. In this model, oral administration of root extract (500 mg/kg bw. p.o.) for 15 days resulted in significant decreased in the levels of blood glucose, plasma lipids and reactivated post heparin lipoprotein lipase activity in alloxan induced diabetic rats. Furthermore, the root extract (50–500 μg) when tested for its antioxidant activity, inhibited the generation of super oxide anions and hydroxyl radicals, in both enzymic and non enzymic systems in vitro. The results of the present study demonstrated antidyslipidemic and antioxidant activities in root extract of H. rosa sinensis which could be used in prevention of diabetic-dyslipidemia and related complications.

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References

  1. Paranjpe P. Indian medicinal plants, forgotten healers: a guide to Ayurvedic herbal medicine. Delhi, India: Chaukhamba Sanskrit Pratishthan; 2001. p. 89–90, 102–3.

  2. Jadhav VM, Thorat RM, Kadam VJ, Sathe NS. Hibiscus rosa sinensis Linn ‘‘Rudrapuspa’’: a review. J Pharm Res. 2009;2(7):1168–73.

    CAS  Google Scholar 

  3. Stymvoli M, Goldstechn B, Haeftn TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet. 2005;365:1333–45.

    Article  Google Scholar 

  4. Chattopadhyaya R, Pathak D, Jindal DP. Antihyperlipidemic agents. A review. Indian Drugs. 1996;33:85–97.

    CAS  Google Scholar 

  5. Kumar V, Singh P, Chander R, Mahdi F, Singh S, Singh R, Khanna AK, Saxena JK, Mahdi AA, Singh VK. Hypolipidemic activity of Hibiscus rosa sinensis root in rats. Indian J Biochem Biophys. 2009;46(6):507–10.

    PubMed  CAS  Google Scholar 

  6. Bindoli A, Valante M, Cavallin L. Inhibition of xanthine oxidase and xanthine dehydrogenase activity. Pharmacol Res Commun. 1985;17:831–9.

    Article  PubMed  CAS  Google Scholar 

  7. McCord JM, Fridovich IJ. Superoxide dismutase; an enzymic function for erythrocuprein (hemocuprein). J Biol Chem. 1969;244:6049–55.

    PubMed  CAS  Google Scholar 

  8. Richmond R, Halliwell R, Chauhan J, Darbre A. Superoxide dependent formation of hydroxyl radical by hydroxylation of aromatic compounds. Anal Biochem. 1981;118:320–35.

    Article  Google Scholar 

  9. Halliwell B, Gutteridge JMC, Aroma OI. The deoxyribose method: a simple test tube assay for determination of rate constants for reaction OH radicals. Anal Biochem. 1987;165:215–9.

    Article  PubMed  CAS  Google Scholar 

  10. Trivedi NA, Mazumdar B, Bhatt JD, Hemavathi KG. Effect of shilajit on blood glucose and lipid profile in alloxan induced diabetic rats. Indian J Pharmacol. 2004;36(6):373–6.

    CAS  Google Scholar 

  11. Gupta V, Bansal P, Garg A, Meena AK. Pharmacopoeial standardization of Hibiscus rosa sinensis Linn. Int J Pharmaceut Clin Res. 2009;1:124–6.

    Google Scholar 

  12. Nakatani M, Matsouka K, Uchio Y, Hase T. Two aliphatic enone ethers from Hibiscus rosa sinensis. Phytochemistry. 1994;35(5):1245–7.

    Article  CAS  Google Scholar 

  13. Mandade R, Sreenivas SA. Anti-diabetic effects of aqueous ethanolic extract of Hibiscus rosa sinensis L. on streptozotocin-induced diabetic rats and the possible morphologic changes in the liver and kidney. Int J Pharmacol. 2011;3:363–9.

    Google Scholar 

  14. Bhuvana S, Mahesh R, Hazing-begum VM. Antioxidant activities of Hibiscus rosa-sinensis linn. During 10 % d-glucose feeding in rat heart tissues. J Food Biochem. 2011;35:792–802.

    Article  CAS  Google Scholar 

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Correspondence to Farzana Mahdi.

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Kumar, V., Mahdi, F., Khanna, A.K. et al. Antidyslipidemic and Antioxidant Activities of Hibiscus rosa sinensis Root Extract in Alloxan Induced Diabetic Rats. Ind J Clin Biochem 28, 46–50 (2013). https://doi.org/10.1007/s12291-012-0223-x

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  • DOI: https://doi.org/10.1007/s12291-012-0223-x

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