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Updates on Novel Erythropoiesis-Stimulating Agents: Clinical and Molecular Approach

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Abstract

Erythropoietin (EPO) is an important hormone responsible for the stimulation of hematopoiesis which is impaired in a variety of diseases, such as chronic kidney disease, cancer chemotherapy, and the use of some anti-HIV drugs. Difficulties in the purification of endogenous EPO due to problems such as technical limitations, heterogeneity of target cells, inadequate amount and immunogenicity of the resultant product, had limited the entry of endogenous EPO in the clinical applications. The integration of medical biotechnology and hematology has introduced novel procedures for the production of human recombinant erythropoietin (rHuEPO), and other erythropoiesis-stimulating agents (ESAs). To investigate and produce rHuEPO, the first step is to recognize the molecular biology and functional pathways, structure, metabolism, and basic physiology of EPO. In this review, all clinical indications, side effects, challenges and notable points regarding EPO, rHuEPO, and other ESAs have also been addressed along with its molecular characterization, such as the modifications needed to optimize their rHuEPO biosynthesis.

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Authors and Affiliations

  1. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran

    Zahra Moradi

  2. Student Research Committee, Babol University of Medical Sciences, Babol, Iran

    Amirhosein Maali, Javad Sadeghi Shad & Mona Moghadami

  3. Department of Medical Biotechnology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

    Amirhosein Maali & Mona Moghadami

  4. Department of Clinical Biochemistry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran

    Javad Sadeghi Shad

  5. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

    Alireza Farasat

  6. Faculty of Allied Medicine, Qazvin University of Medical Sciences, Qazvin, Iran

    Reza Kouchaki, Mohamad Hosein Ahmadi & Mehdi Azad

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Moradi, Z., Maali, A., Shad, J.S. et al. Updates on Novel Erythropoiesis-Stimulating Agents: Clinical and Molecular Approach. Indian J Hematol Blood Transfus 36, 26–36 (2020). https://doi.org/10.1007/s12288-019-01170-1

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