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Congenital Leukemia

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Congenital leukemia is a rare but a well-documented disease in which leukemic process is detected at birth or very shortly thereafter (Philip McCoy and Roy Overton, Commun Clin Cytom 22:85–88, 1995). These leukemias represent approximately 0.8 % of all childhood leukemias. We present a case of congenital acute myeloid leukemia manifesting from the very first day of birth. Diagnosis of acute myeloid leukemia was suspected by the presence of blasts in the peripheral blood smear and was confirmed on bone marrow by flowcytometry. Karyotyping revealed Trisomy 21.

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References

  1. Philip McCoy J Jr, Roy Overton W (1995) Immunophenotyping of Congenital Leukemia. Cytom Commun Clin Cytom 22:85–88

    Article  Google Scholar 

  2. Prashad HVR, Kumar GN (2007) Congenital leukemia in a two month old boy. Internet J Pediat Neonatol 6(2):1–2

    Google Scholar 

  3. Kaneko Y, Shikano T, maseka N (1998) Clinical characteristics of infants acute leukemia 12:672–680

    Google Scholar 

  4. Perkins SL (2007) Hematopoietic system. In: Gilbert-Barness E (ed) Potter’s pathology of the fetus, infant and child. Mosby Inc, Philadelphia, pp 1453–1514

    Google Scholar 

  5. Campwell WA, Storlazzi E, Vintizileos AM (1962) Fetal neonatal leukemia. Arch Dis Child 37:93–98

    Article  Google Scholar 

  6. Iqbal W, Khan Fl, Muzaffar M, Khan UA, Mehmood-ur-Rehman, Khan MasoodA, Bari A (2005) Congenital Leukemia in Down Syndrome. Intern J Pathol 3(2):100–101

    Google Scholar 

  7. Prakash Kp, Rau Atk, Bhat St, Rau Ar (2008) Congenital Leukemia—A diagnostic dilemma. Indian J Med Paediatr Oncol 4:41–43

    Google Scholar 

  8. Pui CH (1995) Childhood leukemia. N Engl J Med 332:1618–1625

    Article  PubMed  CAS  Google Scholar 

  9. Badhe PB, Sane SY (1992) Congenital leukemia-organ involvement in six autopsy cases. J Post Grad Med 38:127

    CAS  Google Scholar 

  10. Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children’s Oncology Group Study A2971. Blood December 22, 2011; 26: 6752–6759

  11. Tragiannidis A, Pana ZD, Papageorgiou T, Hatzipantelis E, Hatzistilianou M, Athanassiadou F (2011) Transient myeloproliferative disease in newborn with Down Syndrome treated with rasburicase for the risk of development of Tumor Lysis Syndrome. J Med Case Rep 5:407

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Gauhati Medical College and Hospital, Guwahati, Assam, India

    Aishwarya Raj

  2. Department of Clinical Haematology, Gauhati Medical College and Hospital, Guwahati, Assam, India

    Sewali Talukdar, Smita Das, Pabitra Kumar Gogoi, Damodar Das & Jina Bhattacharya

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  1. Aishwarya Raj
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  2. Sewali Talukdar
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  3. Smita Das
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  4. Pabitra Kumar Gogoi
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  5. Damodar Das
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  6. Jina Bhattacharya
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Correspondence to Aishwarya Raj.

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Raj, A., Talukdar, S., Das, S. et al. Congenital Leukemia. Indian J Hematol Blood Transfus 30 (Suppl 1), 159–161 (2014). https://doi.org/10.1007/s12288-013-0307-7

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  • DOI: https://doi.org/10.1007/s12288-013-0307-7

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