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Anti-M Antibody in Solid Tumors-Two Case Reports

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Anti-M antibodies are usually of IgM, appear as cold agglutinins and are clinically insignificant. We are reporting two cases of anti-M in cases of solid tumors where the anti-M caused discrepancy in blood grouping, reacted in coombs phase of crossmatching. Anti-M in first case showed dosage effect. These antibodies can be clinical significant when detected in coombs phase, making M antigen negative coombs compatible unit transfusion imperative.

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Acknowledgments

We would like to thank Mr. Sumit Gupta (Bio-Rad) for his contribution and support.

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Authors and Affiliations

  1. Department of Transfusion Medicine and Laboratory Services, BLK Superspeciality Hospital, Pusa Road, New Delhi, 110005, India

    Shiv Kumar Soni, S. K. Sood & Rasika Setia

  2. Department of Medical Oncology, BLK Superspeciality Hospital, Pusa Road, New Delhi, 110005, India

    Hari Goyal

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  1. Shiv Kumar Soni
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  2. Hari Goyal
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  3. S. K. Sood
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  4. Rasika Setia
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Correspondence to Rasika Setia.

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Soni, S.K., Goyal, H., Sood, S.K. et al. Anti-M Antibody in Solid Tumors-Two Case Reports. Indian J Hematol Blood Transfus 30 (Suppl 1), 49–53 (2014). https://doi.org/10.1007/s12288-013-0243-6

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  • DOI: https://doi.org/10.1007/s12288-013-0243-6

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