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Pharmacogenetic association between GSTP1 genetic polymorphism and febrile neutropenia in Japanese patients with early breast cancer

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Abstract

Background

Genetic risk factors for febrile neutropenia (FN), the major adverse event of perioperative chemotherapy for early breast cancer, remain unclear.

Methods

This study retrospectively explored pharmacogenetic associations of single nucleotide polymorphisms (SNPs) of the uridine glucuronosyltransferase 2B7 (UGT2B7, rs7668258), glutathione-S-transferase pi 1 (GSTP1, rs1695), and microcephalin 1 (MCPH1, rs2916733) genes with chemotherapy-related adverse events in 102 Japanese women who received epirubicin and cyclophosphamide as perioperative chemotherapy for early breast cancer.

Results

The allele frequencies for all of the SNPs were in concordance with the Hap-Map data of Japanese individuals. Among the 24 patients who had FN at least once during all courses of chemotherapy, 23 had the A/A genotype, and 1 had the A/G genotype of the GSTP1 polymorphism (rs1695, P = 0.001); 23 of the 70 patients with the A/A genotype had FN, as compared with only 1 of the 32 patients with the A/G and G/G genotypes. The genotype distributions of the UGT2B7 and MCPH1 polymorphisms did not differ between the patients who had FN or grade 3/4 neutropenia and those who did not.

Conclusion

Among Japanese women who received epirubicin and cyclophosphamide as perioperative chemotherapy for early breast cancer, those with the A/A genotype of the GSTP1 polymorphism (rs1695) were more likely to have FN.

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Acknowledgments

This work was supported by the Japan Research Foundation for Clinical Pharmacology (71-014702).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8560, Japan

    Mihoko Sugishita, Ayako Mitsuma, Tomoya Shimokata, Takashi Shibata, Sachi Morita, Megumi Inada-Inoue & Yuichi Ando

  2. Division of Breast and Endocrine Surgery, Department of Surgery, Aichi Medical University, Aichi, Japan

    Tsuneo Imai

  3. Department of Breast and Endocrine Surgery, Nagoya University Hospital, Aichi, Japan

    Toyone Kikumori

  4. Department of Breast Oncology, Aichi Cancer Center Hospital, Aichi, Japan

    Masataka Sawaki

  5. Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan

    Yoshinori Hasegawa

Authors
  1. Mihoko Sugishita
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  2. Tsuneo Imai
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  3. Toyone Kikumori
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  4. Ayako Mitsuma
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  8. Megumi Inada-Inoue
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  10. Yoshinori Hasegawa
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  11. Yuichi Ando
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Corresponding author

Correspondence to Mihoko Sugishita.

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Sugishita, M., Imai, T., Kikumori, T. et al. Pharmacogenetic association between GSTP1 genetic polymorphism and febrile neutropenia in Japanese patients with early breast cancer. Breast Cancer 23, 195–201 (2016). https://doi.org/10.1007/s12282-014-0547-x

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  • DOI: https://doi.org/10.1007/s12282-014-0547-x

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